Protein Alignment nAChRalpha5 and acr-21

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001355512.1
• Gene: acr-21 / 185004
• WormBaseID: WBGene00000060
• Length: 635
• Species: Caenorhabditis elegans
• Alignment Length: 629
• Identity: 195/629 - (31%)
• Similarity: 305/629 - (48%)
• Gaps: 133/629 - (21%)

  Fly   294 IFLLIYLN-------LSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIID 351
            |.|.::.|       ||::   |..:..||..|||..||...||.::..:|:.::|..:|.||||
 Worm     8 ISLFLFFNGAHGGNELSSR---ADQNVMRLYRDLLYDYNNEVRPSVHSKEPINVTFVFSLTQIID 69

  Fly   352 VDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGF-DGTYQT 415
            |||:||:|.||.|::|.|.|..|.|:...|..|..:.||..:|||||:::||:||..: .....|
 Worm    70 VDERNQILTTNSWIRLHWVDYKLVWDPRLYQNVTRIHIPSDKIWKPDIILYNNADAQYMKSVMST 134

  Fly   416 NVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSY 480
            :|:|...|:..:....||.|:|.:|:..:|||.|.|.:|:.||.|||.::||.|:.|. ||:::|
 Worm   135 DVIVDYLGNIHWPLSAIFTSSCPLDVKHYPFDRQTCILKYASWAYDGTKIDLLLKSEQ-GDLTNY 198

  Fly   481 VLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLP 545
            :.|.||.|:|:..::|::.|:||||||..|...:.|.||.::|.||||:|||||:.:||:||.:|
 Worm   199 ITNTEWSLIGIRAEKNQVIYSCCPEPYPFIDVHVTIERRAMFYVFNLILPCVLISLIALMGFYMP 263

  Fly   546 PDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHR 610
            .|||||::||:|.|||.||||.||||.||.|::|:||:|.||...:.:||.....|:..:|.||.
 Worm   264 TDSGEKVTLGITSLLSTTVFLMMVAEGMPPTAEALPLIGIYFGVTIMLVALGTAMTVFTVNIHHT 328

  Fly   611 NADTHEMSEWIRIVFLCWLPWIL--------RMSRPGRPLILEFPTTPCSDTSS---ERKHQILS 664
            ....:.:..:::|....:|..||        .::...|.:..:...|.|:.::|   :|.|...:
 Worm   329 GVHGYPVPPFLQIFAFRYLSKILFVRIEPYHSIAHHVRYMYQKEHPTECTLSASVHYKRLHDFDA 393

  Fly   665 DVELKER--------SSKSLL-ANV-LDIDD----------------DFRHNCRPM--------- 694
            :|..||.        |:.|:: ||| .:.||                |...|.|..
 Worm   394 NVAKKEEQYGLQRDMSNLSVISANVHCNPDDRLLLGSQSSQKNLNKFDSEKNLRSSLSIRSGSPT 458

  Fly   695 ------------------------------------TP----------GGTLPHNP-AFYRTVYG 712
                                                ||          |.|....| :.||...|
 Worm   459 AKKKGHVRVSNIARSTRIMETDVSHLVSFSSLNSHGTPIDSPIYGRKLGRTQSQTPTSSYRNSNG 523

  Fly   713 QGDDGSIGPIGSTRMPDAVTHHTCIK------------------SSTEYELGLILKEIRFITD-- 757
            .|.      |.|..:|..:::...|.                  ...|.|...::..:..|.:
 Worm   524 NGG------ITSDPLPQQLSNPPKISLTDVDDVFENNENQQPMVDEFEKEFLRVMSMVHGIIERN 582

  Fly   758 --QLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVL 799
              ::.:.|:.:.||.:|:..|||:||..|::|.:.|.::|..:|
 Worm   583 EMRVAEKDKRDAIALEWQQVAMVLDRFLLVVFLIGTSMSTFVIL 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	189/603 (31%)
acr-21	NP_001355512.1	LGIC_ECD_nAChR	56..237	CDD:349798	75/181 (41%)
		Cys-loop	156..170	CDD:349798	6/13 (46%)
		LGIC_TM_cation	239..>327	CDD:349853	47/87 (54%)
		TM1 helix	239..263	CDD:349853	14/23 (61%)
		TM2 helix	271..292	CDD:349853	14/20 (70%)
		TM3 helix	303..325	CDD:349853	5/21 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920