DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha5 and lgc-31

DIOPT Version :9

Sequence 1:NP_001356885.1 Gene:nAChRalpha5 / 34826 FlyBaseID:FBgn0028875 Length:837 Species:Drosophila melanogaster
Sequence 2:NP_001256671.1 Gene:lgc-31 / 184752 WormBaseID:WBGene00008997 Length:675 Species:Caenorhabditis elegans


Alignment Length:536 Identity:138/536 - (25%)
Similarity:228/536 - (42%) Gaps:81/536 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   315 RLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTS 379
            ||..|||..|....|||.:....:.:|..:.|.||:.:|.....:..:...:|.|.|..|:||.|
 Worm   130 RLHDDLLRYYRKGTRPVTHPKKVISVSMSVFLYQIVKLDAVKNTISLSGSFELYWEDEFLKWNPS 194

  Fly   380 DYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNN--GSCLYVPPGIFKSTCKIDIT 442
            .|.|.:::.:....||.|:..:|.|.:.......|:|..||.|  |...|..|...:|.||:|:.
 Worm   195 SYEGAEEIFLSSSDIWIPEFSLYYSLNFNDAVKLQSNNDVRVNYTGQVRYYIPFSSESLCKLDVK 259

  Fly   443 WFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGKRNEIYYNCCPEPY 507
            :||||.|:|.:.||||.:....:...|..:....|..|. |.||||   ....:.::.:.....|
 Worm   260 FFPFDVQQCSLLFGSWAHSNDSIKYSLYSQNLSLIDFYD-NQEWEL---DTHNSSVHSDGFLYDY 320

  Fly   508 ID-------ITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGE----KLSLGVTILLS 561
            :|       |...::::|::.||.|||:||..:|..::::||..|..||.    |..||:..|:|
 Worm   321 LDPPLFWEMIIITLVMKRQSFYYVFNLVIPSTMITLVSVIGFHTPSTSGRMRDAKFRLGIMTLMS 385

  Fly   562 LTVFLNMVAETMPATS-----------DAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTH 615
            ::|.|..:.|.||..|           ..:||:|.|:..::.::..|.|:|.:.: |..|.:...
 Worm   386 MSVILLAIVEDMPKFSMGTNRRGRGSFSGIPLIGLYYFILLAIIGMSTVTTSMFV-YLERESRVK 449

  Fly   616 EMSEWIRIVFLCWLPWILRMSRPGRPLILEFP---TTPCSDTSSERKHQILSDVELKERSSKSLL 677
            ....|    :|.||.:.:..|:..|.|....|   :.|.|:......| :.|.:..|.|...:.|
 Worm   450 MNVPW----YLKWLSFDISPSKIARKLSRYRPQAMSQPPSEHLLSNGH-VRSGIRDKARGVAASL 509

  Fly   678 ANVLDIDDDFRHNCRPMT------PGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTC 736
            .::|.         ||.:      |||...::|...:.::....|.......|.|...:::.:..
 Worm   510 LSLLP---------RPGSGVGNGGPGGDNGNSPFHMQHLHAYHQDNPTPARESIRRRLSMSQYDN 565

  Fly   737 IKSSTEYELGL------------ILKEIR-----FITDQLRKDDECNDIANDWKFAAMVVDRL-C 783
            :.....||..|            .:.|||     |:..        :||...|:   .|:.|| .
 Worm   566 MLIYQYYEQALEDIANGVSRMAGSIAEIRSEMMAFLPQ--------DDINTKWQ---TVIRRLEI 619

  Fly   784 LIIFTMFTILATIAVL 799
            |.:|...::|.|...|
 Worm   620 LSLFFYVSVLFTTMYL 635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha5NP_001356885.1 LIC 313..802 CDD:273305 138/536 (26%)
lgc-31NP_001256671.1 TM_EphA1 <43..>79 CDD:391457
LGIC_ECD_cation 153..339 CDD:349790 52/189 (28%)
LGIC_TM_cation 341..>442 CDD:349853 31/101 (31%)
TM1 helix 345..365 CDD:349853 8/19 (42%)
Neur_chan_memb 347..634 CDD:367256 71/312 (23%)
TM2 helix 377..398 CDD:349853 7/20 (35%)
TM3 helix 420..442 CDD:349853 4/22 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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