Protein Alignment nAChRalpha5 and lgc-5

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_501411.4
• Gene: lgc-5 / 184620
• WormBaseID: WBGene00017543
• Length: 433
• Species: Caenorhabditis elegans
• Alignment Length: 531
• Identity: 116/531 - (21%)
• Similarity: 208/531 - (39%)
• Gaps: 129/531 - (24%)

  Fly   292 SWIF--LLIYLNL---SAKVCLAGYHEKRLLHDLLD--------PYNTLERPVLNESDPLQLSFG 343
            ||:.  ||.:|.|   .:.......:.:.||.:|.:        |.:||....:..:..|.||
 Worm     2 SWLLNSLLTFLVLRTFGSNTTNVESNTEVLLQELFNRTYDVNVKPSDTLTTVTITPNTFLLLS-- 64

  Fly   344 LTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTS--DYGGVKDLRIPPHRIWKPDVLMYN--S 404
                    :|:..:.::.:....|:|.|..|.||.:  ||.. :.::|...|:|.|||:...  |
 Worm    65 --------MDQTQETILFSQEFLLKWYDPILHWNRTLFDYNR-EWIKISVSRVWVPDVIFTKRLS 120

  Fly   405 ADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQL 469
            .:...|...|. ..:|.||......|.:..::|.::|..||.|.|.|.:..|||.:|...:.:|.
 Worm   121 VESLLDEDMQM-ADLRYNGEIRTSLPAVVSTSCPLNIQDFPHDVQECNISMGSWAFDRTVIVVQS 184

  Fly   470 Q-DETGGDISSYVLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVL 533
            . ||.......:..|.|||||.:...|.:.:.......:.:||:.:.::|:.:||...:..|..:
 Worm   185 SVDEILPLRGRFEGNSEWELLSIRAFRTDSFEYSLGTSFSEITYTVTLQRKPVYYVLVIQAPTFI 249

  Fly   534 IASMALLGFTLPPDSGE-----KLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFM 593
            :.::.:.|. ..|:|.|     ::.|.:.:..::::.|.:|::.||..| .:||||.|....:|:
 Worm   250 LCTITIFGL-FSPNSNENERLSRVELCLNMFAAISMMLQLVSDMMPKAS-RLPLLGNYIIAEIFV 312

  Fly   594 VASSVVSTILILNYHHR---NADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTS 655
            |.::.::.|:|.:.||.   ||..  ..:|:|.:.||            ..:..|||:...|.:|
 Worm   313 VTAATIAAIVIQHVHHHVHTNATC--PPKWLRCLVLC------------DCMREEFPSKTSSVSS 363

  Fly   656 SERKHQILSDVELKERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIG 720
            .:....|::.|        |||.:.|                    |..||
 Worm   364 MDVPENIIAPV--------SLLKSSL--------------------HKTAF-------------- 386

  Fly   721 PIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLI 785
                                             .:.|.|::....|:....|.......|.:|||
 Worm   387 ---------------------------------LVRDTLQEMSRINENQLLWLKILDKTDLMCLI 418

  Fly   786 IFTMFTILATI 796
            :|.:..::.||
 Worm   419 LFQVANVVITI 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	110/505 (22%)
lgc-5	NP_501411.4	LGIC_ECD_cation	51..235	CDD:349790	48/195 (25%)
		Cys-loop	152..166	CDD:349790	6/13 (46%)
		LGIC_TM	238..>323	CDD:476813	21/86 (24%)
		TM1 helix	241..261	CDD:349853	2/20 (10%)
		TM2 helix	273..294	CDD:349853	3/20 (15%)
		TM3 helix	304..323	CDD:349853	4/18 (22%)