Protein Alignment nAChRalpha5 and acr-12

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_510262.1
• Gene: acr-12 / 181475
• WormBaseID: WBGene00000051
• Length: 573
• Species: Caenorhabditis elegans
• Alignment Length: 600
• Identity: 201/600 - (33%)
• Similarity: 311/600 - (51%)
• Gaps: 105/600 - (17%)

  Fly   292 SWIFLLIYLNLSAKVCLAGYH-----------EKRLLHDLLDPYNTLERPVLNESDPLQLSFGLT 345
            :|..:|:       |.:.|.:           |.:|..|||..||.:.|||.|.||.|.:..|.:
 Worm    13 NWALILL-------VAVGGTNAFKIKRTAKDLESQLYEDLLFDYNKVPRPVKNSSDILTVDVGAS 70

  Fly   346 LMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFD 410
            |::|||||||||:|.||:||:::|||..|.|....|||:|.|.||...||.||:::||:|....|
 Worm    71 LIRIIDVDEKNQVLTTNLWLEMKWNDAKLTWTPEKYGGLKTLHIPSDFIWTPDLVLYNNAAGDPD 135

  Fly   411 GTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDL-QLQDE-- 472
            .|..|:.:|...|:..:.||.|:||.|.||:||||:|.|:||||||:|||.|..:|| ||..|
 Worm   136 ITILTDALVTFEGNVYWQPPAIYKSFCPIDVTWFPYDSQKCEMKFGTWTYTGRYVDLKQLPQEEV 200

  Fly   473 --------------TGGDISSYVLNGEWELLGVPGKRNEIYY-NCC-PEPYIDITFAIIIRRRTL 521
                          .|.|:|.:..:.||:||.:..:|:.:.| :|| ||.|:|||:...:||:||
 Worm   201 VTITKDDNDVEFMQQGMDLSFFYRSAEWDLLSLTSERHSVLYASCCGPEKYVDITYYFGLRRKTL 265

  Fly   522 YYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTY 586
            ::..|||:||.||:.:....|.|   |..|::..::||::||||..::.:.||.||..:|:.|.|
 Worm   266 FFTCNLILPCFLISILTTFVFYL---SDHKITFSISILVTLTVFFLVLIDLMPPTSLVIPMFGRY 327

  Fly   587 FNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPC 651
            ....|.:||.|.|.:::.:|:..|:...|:||.|||.|||.:||.||.||||.:..:.:.|  |.
 Worm   328 LITTMILVALSTVVSVITVNFRFRSGSAHKMSPWIRAVFLKFLPKILLMSRPEKGEVTKQP--PL 390

  Fly   652 SDTSS--------------------ERKHQILSDVELKERSSKSLLANVLDI-----DDDFRHNC 691
            .:.:|                    :.|:..|..:..|. ||:::|.|..|:     |....:..
 Worm   391 VNAASLVGSNYATAAKAANEYRNKAKGKNNDLMSLRGKP-SSQAVLNNTFDMRMRNNDSTVENRL 454

  Fly   692 RPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFIT 756
            :|.               :..|.::........|:...:       ||..:.....:|.::|||.
 Worm   455 KPY---------------LCAQNNNAPTVAFRKTKRQKS-------KSVDDVVFMNLLNQVRFIA 497

  Fly   757 DQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAPHI----------IVSXPY 811
            :..|.::...:|::||.|.|||:|||.||||::..: .|:.::|.:|.:          :.:.|.
 Worm   498 EHFRHNELEGEISDDWTFVAMVLDRLFLIIFSVLNV-GTVFIILESPSLYDYSKPMNITVPNKPL 561

  Fly   812 GRGGYCYWFYYKINL 826
            |:..    ||...||
 Worm   562 GQAN----FYSSWNL 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	190/532 (36%)
acr-12	NP_510262.1	LIC	14..539	CDD:273305	193/560 (34%)
		Neur_chan_LBD	38..264	CDD:280998	102/225 (45%)
		Neur_chan_memb	271..538	CDD:280999	84/295 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910