Protein Alignment nAChRalpha5 and acr-8

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001361818.1
• Gene: acr-8 / 181246
• WormBaseID: WBGene00000047
• Length: 540
• Species: Caenorhabditis elegans
• Alignment Length: 533
• Identity: 175/533 - (32%)
• Similarity: 287/533 - (53%)
• Gaps: 91/533 - (17%)

  Fly   296 LLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLV 360
            |..|:|       ...:..::..|||..||...||:.|.|:.:::.||.:|::||||||.||:|.
 Worm    15 LFFYVN-------PNRYADQMYEDLLYYYNKNVRPIKNASESVKVKFGSSLIRIIDVDEVNQVLT 72

  Fly   361 TNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSC 425
            ||:||:::|.|..|.|:...:|.::.|.:|..:||.||:|:||:||.....|..::.:|..||..
 Worm    73 TNLWLEMQWFDYRLMWDPGRWGKIRKLHVPVDQIWIPDILLYNNADGEPHITIMSDAIVYYNGLV 137

  Fly   426 LYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDL------------QLQDE------ 472
            ::.||.|:||.|.|||.:||:|.|.|.||||.|||:||.||:            :..||
 Worm   138 VWKPPSIYKSFCSIDIEYFPYDTQTCWMKFGGWTYNGFLLDVRQLPTTGCEVVNKADDEGEFQFL 202

  Fly   473 -TGGDISSYVLNGEWELLGVPGKRNE-IYYNCCPEP-YIDITFAIIIRRRTLYYFFNLIIPCVLI 534
             .|.|:|.|..:.||:|:.:...|:| ||..||.:. ||||||.|.|||:||:|..||:|||.:.
 Worm   203 GRGMDLSGYYPSLEWDLMELNSARHEKIYAGCCGQDFYIDITFKIEIRRKTLFYTINLMIPCTMF 267

  Fly   535 ASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVV 599
            |.:..:.|.:||.. .|::..::||::||||..::.:.:|.||..:||:|.|....||:|:.|::
 Worm   268 AILTSIVFYVPPIE-HKMTFSISILVTLTVFYLILIDLVPPTSLVIPLIGKYLLFTMFLVSISIM 331

  Fly   600 STILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILS 664
            .:::.||::.|:..:..|..|:::||:..||         |.:.::   |...|..|:|...| |
 Worm   332 LSVISLNFYRRDGSSFPMPHWMKVVFIHTLP---------RYICIK---TAEEDDGSDRGSSI-S 383

  Fly   665 DVELKERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRM-P 728
            |:                  ..|..:.||         :| |:.||..:..:|.:..:....| |
 Worm   384 DI------------------GPFMDSRRP---------SP-FFITVNERQLNGRLSELKKKGMHP 420

  Fly   729 DAVTHHTCIKSSTEYELGLILKEIRFITD---QLRKDDECNDIANDWKFAAMVVDRLCLIIFTMF 790
            |.:.:              :::.:.||.:   .|:|:|:   ::.||.:.|.|:||:.||||::.
 Worm   421 DLIRN--------------MIQNVEFIAEYFNSLKKEDK---VSEDWSYVANVIDRIFLIIFSIM 468

  Fly   791 TILATIAVLLSAP 803
            .::.|..:||::|
 Worm   469 NVVGTWVILLNSP 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	171/513 (33%)
acr-8	NP_001361818.1	LGIC_ECD	24..255	CDD:355788	96/230 (42%)
		Neur_chan_memb	260..476	CDD:367256	70/274 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910