Protein Alignment nAChRalpha5 and lgc-4

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_509556.4
• Gene: lgc-4 / 181155
• WormBaseID: WBGene00017580
• Length: 635
• Species: Caenorhabditis elegans
• Alignment Length: 525
• Identity: 176/525 - (33%)
• Similarity: 280/525 - (53%)
• Gaps: 56/525 - (10%)

  Fly   313 EKRLLHDLLD--PYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLR 375
            |:.|...|||  .|....||.::.|.|..::||..|.||:::||:||.|.|..||.:.|.|..|.
 Worm   111 EEALYRSLLDHTVYEKDVRPCIHHSQPTNVTFGFLLNQIVEMDERNQALTTRSWLNINWMDPRLS 175

  Fly   376 WNTSDYGGVKDLRIPPHRIWKPDVLMYNSA-DEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKI 439
            ||.|.:..:|.:.||..||||||:::.|:| .|.:.....|:|:|.::|:..::...:|:|:|.|
 Worm   176 WNESLWSEIKAIYIPHARIWKPDIILVNNAIREYYASLVSTDVMVTSDGNVTWLFSALFRSSCPI 240

  Fly   440 DITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGKRNEIYY-NCC 503
            .:.::|||||:|::||.||::|..:::|.|..:. ||:|||:.|.|::|:.:...|..:.: :..
 Worm   241 RVRYYPFDDQQCDLKFASWSHDITEINLGLNTDK-GDLSSYMNNSEFDLVDMTAVREVVTFPSDT 304

  Fly   504 PEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNM 568
            ...:..|...|.:.||.|:|.||.|:|||||:|||:|||.:||::|||:::.:|.|||:.|:|..
 Worm   305 NSDWPIIVIRIHMHRRPLFYVFNHIVPCVLISSMAVLGFLMPPETGEKINMIITTLLSMGVYLQS 369

  Fly   569 VAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHE-------MSEWIRIVFL 626
            :.|::|.||:.|||:|.|:...:.||..:....::.||. |||...::       |.:||    |
 Worm   370 ITESIPPTSEGVPLIGMYYVSSLLMVCLATCVNVITLNM-HRNGAANQGRHVPAWMQKWI----L 429

  Fly   627 CWLPWILRMS--RPGRPLILEFPTTPCSDTSSERKHQILSDVE-LKERS-----SKSLLAN-VLD 682
            .:|...:|||  .|....:|:   ...|..|:.|:..||.|:: :|..|     ||...|| ..:
 Worm   430 GYLATFMRMSIREPDSIALLK---ASQSKKSTIRRSSILRDLKRVKNMSNVRAKSKEQNANRECE 491

  Fly   683 IDDDFRH-------NC-----RPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHT 735
            ..|...|       :|     :||. |.|:..:.|...|..|:.....|       ||.......
 Worm   492 CMDPLVHIYAESIMSCLAADTKPMN-GSTIREDFASESTFLGRVVSDGI-------MPRISASSN 548

  Fly   736 CIKSSTEYELGLILKEIRFITDQ--LRKD--DECNDIANDWKFAAMVVDRLCLIIF---TMFTIL 793
            .:.:..|.....|||.:.....|  :|::  ||.:.|...|:..|.|||||.|.:|   |:|||:
 Worm   549 SVLTEFETRFRRILKRVYRSLQQHEIREEILDERSRIQWQWQQLASVVDRLLLCLFCTATLFTII 613

  Fly   794 ATIAV 798
            ..:.|
 Worm   614 CLLIV 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	176/525 (34%)
lgc-4	NP_509556.4	LGIC_ECD_nAChR	138..320	CDD:349798	63/182 (35%)
		Cys-loop	238..252	CDD:349798	7/13 (54%)
		LGIC_TM_cation	322..>409	CDD:349853	40/87 (46%)
		TM1 helix	322..346	CDD:349853	16/23 (70%)
		TM2 helix	354..375	CDD:349853	7/20 (35%)
		TM3 helix	386..408	CDD:349853	4/21 (19%)