Protein Alignment nAChRalpha5 and acr-3

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_509129.1
• Gene: acr-3 / 180937
• WormBaseID: WBGene00000043
• Length: 487
• Species: Caenorhabditis elegans
• Alignment Length: 526
• Identity: 173/526 - (32%)
• Similarity: 287/526 - (54%)
• Gaps: 80/526 - (15%)

  Fly   293 WIFLLIYLNLSAKV-CLAGYHEKRLLHDLLDPYNTLERPVLN-ESDPLQLSFGLTLMQIIDVDEK 355
            |:|.:|.:.|..:: |.....|:|||..:.|.||:|.||||| .|.|:::.|.|..:.:|:||||
 Worm     5 WLFSIITIFLITELQCYPNSAEERLLSYIFDGYNSLIRPVLNASSPPIEVFFSLAFVLLINVDEK 69

  Fly   356 NQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVR 420
            ||::.||||..::|||..::|:..::.|:|.:|:||.::|.||::::|:||..:..::.:||||.
 Worm    70 NQIMQTNVWPTMKWNDYQMQWDPREFDGIKTIRVPPDKVWLPDIVLFNNADGNYLVSFYSNVVVE 134

  Fly   421 NNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQ-LQDETGGDISSYVLNG 484
            :.|..|:|||.::||:|.||:.:||||:|.|.:.|||||:...:|.|. |..:...:::.|:.:|
 Worm   135 HTGDMLWVPPAVYKSSCLIDVEFFPFDEQVCSLTFGSWTFRKDELQLSYLSGKRHVELNDYLPSG 199

  Fly   485 EWELLGVPG----KRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLP 545
            .|:|:..||    :|::|.|.            |.|||:.|:|...||:|.||:|.::::.|.||
 Worm   200 VWDLIDAPGLLIDERSKISYQ------------IKIRRKALFYTVILIMPTVLMAFLSMMVFYLP 252

  Fly   546 PDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHR 610
            .:|.||::|.::|||:|.|||.:|::.:|.||..:||:..|......|...:::.:::|:|.:.|
 Worm   253 AESSEKITLAISILLALVVFLLVVSKILPPTSSTIPLMAKYLLMTFIMNMITIMVSVIIINVYFR 317

  Fly   611 NADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKS 675
            ...||.|..|::.|||.:||.:..|.||               .|:|::...:...:.:.||.||
 Worm   318 GPATHIMPNWVKTVFLKFLPVLFVMRRP---------------ESTEKELAKMKREKRERRSMKS 367

  Fly   676 LLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIG--PIGSTRMPDAVTHHTCIK 738
            .|...      |:.|                         |..|.  |..::|...
 Worm   368 ALKTF------FKRN-------------------------DAKISEQPKQTSRKDG--------- 392

  Fly   739 SSTEYELGLILKE----IRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVL 799
            ||:|.:|....|:    |.:||..|..|:.......:|||.::|:|||.|.:|...|...|:.:|
 Worm   393 SSSEEKLSSDAKKAIEAIEYITTHLTHDNAFKRQREEWKFVSVVIDRLLLYLFFAVTTGGTVGIL 457

  Fly   800 LSAPHI 805
            ||||::
 Worm   458 LSAPNV 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	165/500 (33%)
acr-3	NP_509129.1	LIC	5..460	CDD:273305	170/521 (33%)
		Neur_chan_LBD	26..226	CDD:280998	83/211 (39%)
		Neur_chan_memb	234..456	CDD:280999	77/276 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910