Protein Alignment nAChRalpha5 and acr-2

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_509128.1
• Gene: acr-2 / 180936
• WormBaseID: WBGene00000042
• Length: 575
• Species: Caenorhabditis elegans
• Alignment Length: 568
• Identity: 192/568 - (33%)
• Similarity: 306/568 - (53%)
• Gaps: 80/568 - (14%)

  Fly   269 SSSNSSNSGNSSSTQILNGLNKHSWIFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLN 333
            |.:|..:..|||..      ||:           |.:....|..|.||:.||...||.|.|||.|
 Worm    33 SHTNIDDPNNSSDP------NKN-----------SDQGDTMGEDEDRLVIDLFREYNFLIRPVKN 80

  Fly   334 -ESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKP 397
             .|.|:.:.||:.::.:|:||||||:|.|||||.::|||..|.||.::||.:.:|.:|..|:|.|
 Worm    81 VSSPPVVVDFGVAMILLINVDEKNQILQTNVWLTMKWNDFQLAWNPAEYGNISNLHVPSDRVWLP 145

  Fly   398 DVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDG 462
            |::::|:||..::.::::||.|.::|...:|||.:|||:|:||:.|||||:|.|.:.||||||:.
 Worm   146 DIVLFNNADGNYEVSFKSNVFVDHHGDVTWVPPAMFKSSCRIDVEWFPFDEQCCTLVFGSWTYNS 210

  Fly   463 FQLDL---------QLQDETGGDISSYVLNGEWELLGVPG--------KRNEIYYNCCPEPYIDI 510
            .::.|         ||.|        |..:|.|:::.|||        |.|::.:|
 Worm   211 EEVRLHWYNNIQAVQLHD--------YSYSGIWDVIDVPGQLVHKPDLKENKMVFN--------- 258

  Fly   511 TFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPA 575
               ::|||:||:|...||||.||:|.::::.|.||.|||||:||.:::||:|.|||.:|::.:|.
 Worm   259 ---VVIRRKTLFYTVILIIPTVLMAFLSVMAFYLPVDSGEKVSLTISLLLALVVFLLLVSKILPP 320

  Fly   576 TSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGR 640
            ||: :||:|.|......:..::||.|::|:|.:.|:|.:|:|..|:|.|||.:||.:|.|.||.|
 Worm   321 TSN-IPLMGKYLLLAFVLNITAVVGTVVIVNIYFRSALSHKMPTWVRKVFLEFLPHLLVMKRPER 384

  Fly   641 -PL-----ILEFPTTPCSDTSSERKHQILS-------DVELKERSSKSLLANVLDIDDDFRHNCR 692
             |:     :.|:..:...|.|........:       ...||..||.|     .....:...||.
 Worm   385 IPIFNGYFVEEYCASEIFDASLVMPSMTATMLPFLQVTTNLKAASSTS-----SGQSSEHHENCS 444

  Fly   693 PMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITD 757
            ....  .|....:..|....:.||.|...|..|.    ..|...::.....|:...::.|.:|.:
 Worm   445 KWKK--RLSIRMSKRRAPRARLDDDSEDIIDDTN----GNHVDSLQEKISKEMKTTVEAIAYIAE 503

  Fly   758 QLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAPHI 805
            .::::.....:.:|||:.|||:|||.|:||...|:..|:.::.||||:
 Worm   504 HMKREMSLKKMRDDWKYVAMVLDRLILLIFFGVTLGGTLGIICSAPHV 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	179/519 (34%)
acr-2	NP_509128.1	LIC	54..544	CDD:455710	180/521 (35%)
		LGIC_ECD_nAChR_proto_beta-like	59..265	CDD:349833	88/225 (39%)
		Cys-loop	185..199	CDD:349833	9/13 (69%)