DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha5 and des-2

DIOPT Version :9

Sequence 1:NP_001356885.1 Gene:nAChRalpha5 / 34826 FlyBaseID:FBgn0028875 Length:837 Species:Drosophila melanogaster
Sequence 2:NP_001380111.1 Gene:des-2 / 179574 WormBaseID:WBGene00000955 Length:559 Species:Caenorhabditis elegans


Alignment Length:583 Identity:163/583 - (27%)
Similarity:263/583 - (45%) Gaps:101/583 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   298 IYLNLSAKVCLAGY---HEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLL 359
            :.|..:|.:|:|..   .:.||:|||||.|:...:|:.:.|.|:.:||.:.|.||::::|..|.:
 Worm     8 LLLATTASLCIADTPVPTQIRLVHDLLDNYDKKAKPMWDNSKPINVSFSMDLYQILELNEPQQYI 72

  Fly   360 VTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQ------TNVV 418
            :.|.|:...|.|..|.||..||..:.:||:|...||.||..:|||.....|.|.:      |...
 Worm    73 LLNAWIIERWFDEFLYWNPDDYENITELRLPYDSIWLPDTTLYNSLVMKDDDTRRLLNSKLTTDT 137

  Fly   419 VRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLD-LQLQDETGGDISSYVL 482
            .|.......:.|.|:|.:|.:|:.:||||.|.|.|.|.|||||...:| ....|:.|  .|:|:.
 Worm   138 HRRAALIELLYPTIYKFSCLLDLRFFPFDVQVCTMTFSSWTYDQKGIDYFPYSDKIG--TSNYLE 200

  Fly   483 NGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLG-FTLPP 546
            |..|.:|....||.|:.|.|||..|..:...:.:||:.|:|..|||||..:|..:|::| ||...
 Worm   201 NEGWYILQTKIKRQEVKYACCPNNYTLLQLTLYLRRKPLFYLVNLIIPTSIITLIAIVGFFTTSS 265

  Fly   547 DSG---EKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYH 608
            .||   ||:|||:|.|||:::.:.||::.||.||..:||:|.:...::.:::...|.:.:|:...
 Worm   266 ASGMREEKVSLGITTLLSMSILMLMVSDQMPTTSTFIPLIGWFILAMIIVISLGTVVSSVIIAIQ 330

  Fly   609 HRNADTHEMSEWIRIVFLCWLPWILRMSRPGR--------------PLILEFPTTPCSDTSSERK 659
            .|.:....||: ..:.|...|.|....|.|..              ||:...|....|...|.| 
 Worm   331 KRGSLGERMSK-RALKFAKVLAWFTCTSLPPHVEKEHMMEAFDAPTPLVEVRPLQLASVKESVR- 393

  Fly   660 HQILSDVELKERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPI-- 722
            ::.:|......:...|.||.:.|...|      |:.......|.|           |.||.|.  
 Worm   394 NKWVSGARRATQRGNSGLALISDKSTD------PLIHLSPTAHQP-----------DESISPSAP 441

  Fly   723 ---GSTRMPDAVTHHTCIKSSTEYELGLILKEI--RFITDQLR-KDDECNDIA------------ 769
               .|:.:|..:|      .....::..:..|:  :|:|.::| |..:.|..|            
 Worm   442 PVPSSSPLPPPLT------PGPADDVVSVASELSSKFLTSRMRPKSQKDNTFAAMQRAGLSRSSM 500

  Fly   770 -------------NDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAPHIIVSXPYGRGGYCYW 819
                         .::::.|.||:|.|.:||.:..::.|..:     :.|        |:.:|
 Worm   501 RQGSIKANRQLAVAEFEWFATVVERTCFVIFVVAFLIITFGI-----NFI--------GFIHW 550

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha5NP_001356885.1 LIC 313..802 CDD:273305 156/546 (29%)
des-2NP_001380111.1 Neur_chan_LBD 28..222 CDD:397192 72/195 (37%)
LGIC_TM_cation 239..>332 CDD:349853 34/92 (37%)
TM1 helix 243..263 CDD:349853 9/19 (47%)
TM2 helix 275..296 CDD:349853 9/20 (45%)
TM3 helix 307..329 CDD:349853 2/21 (10%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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