Protein Alignment nAChRalpha5 and acr-16

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_505207.1
• Gene: acr-16 / 179235
• WormBaseID: WBGene00000055
• Length: 498
• Species: Caenorhabditis elegans
• Alignment Length: 526
• Identity: 244/526 - (46%)
• Similarity: 326/526 - (61%)
• Gaps: 49/526 - (9%)

  Fly   296 LLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLV 360
            |||...:.|...|....|:||..||:..||.|||||.|.|:|:.:...:.|.||||||||||::.
 Worm     6 LLISCAILAAPTLGSLQERRLYEDLMRNYNNLERPVANHSEPVTVHLKVALQQIIDVDEKNQVVY 70

  Fly   361 TNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSC 425
            .|.||...|||.||.|:.::||.:.|:|.|..:|||||||:|||.|..||.|||||::|.:.|..
 Worm    71 VNAWLDYTWNDYNLVWDKAEYGNITDVRFPAGKIWKPDVLLYNSVDTNFDSTYQTNMIVYSTGLV 135

  Fly   426 LYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGG-DISSYVLNGEWELL 489
            .:|||||||.:|||||.|||||:|:|..|||||||||::||  ||..||| |||.|:.||||.|.
 Worm   136 HWVPPGIFKISCKIDIQWFPFDEQKCFFKFGSWTYDGYKLD--LQPATGGFDISEYISNGEWALP 198

  Fly   490 GVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSL 554
            ....:|||.:|:||||||.|:.|.:.:|||||||.||||:||:|...|.|||||||||:|||::|
 Worm   199 LTTVERNEKFYDCCPEPYPDVHFYLHMRRRTLYYGFNLIMPCILTTLMTLLGFTLPPDAGEKITL 263

  Fly   555 GVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSE 619
            .:|:|||:..||::|:|..|.||:||||||.:|.|.|.:|.:|.|.|:.:||.|:|..:||:|..
 Worm   264 QITVLLSICFFLSIVSEMSPPTSEAVPLLGIFFTCCMIVVTASTVFTVYVLNLHYRTPETHDMGP 328

  Fly   620 WIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANVLD-- 682
            |.|.:.|.|:||||||.|||..  |.:.:.|...::...:|            |:||:.|:.|
 Worm   329 WTRNLLLYWIPWILRMKRPGHN--LTYASLPSLFSTKPNRH------------SESLIRNIKDNE 379

  Fly   683 --------IDDDFRHNCRPMTP----GGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHT 735
                    .|.|.|.|...||.    |.|                  |:|.|.||.:....|...
 Worm   380 HSLSRANSFDADCRLNQYIMTQSVSNGLT------------------SLGSIPSTMISSNGTTTD 426

  Fly   736 CIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLL 800
            ..:.:|...|..|..|::.:|.::.:.|:.....|:|||||||||||||.:||:|.|::||.:..
 Worm   427 VSQQATLLILHRIYHELKIVTKRMIEGDKEEQACNNWKFAAMVVDRLCLYVFTIFIIVSTIGIFW 491

  Fly   801 SAPHII 806
            |||:::
 Worm   492 SAPYLV 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	236/503 (47%)
acr-16	NP_505207.1	LIC	6..493	CDD:273305	241/520 (46%)
		Neur_chan_LBD	23..229	CDD:280998	118/207 (57%)
		Neur_chan_memb	236..490	CDD:280999	111/285 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	261	1.000	Domainoid score	I1050
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H593
Inparanoid	1	1.050	470	1.000	Inparanoid score	I838
Isobase	1	0.950	-	0	Normalized mean entropy	S3299
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	1	1.000	-	-		mtm4815
orthoMCL	1	0.900	-	-		OOG6_104534
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3025
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.950