DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha5 and eat-2

DIOPT Version :9

Sequence 1:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_496959.1	Gene:	eat-2 / 175072	WormBaseID:	WBGene00001133	Length:	474	Species:	Caenorhabditis elegans

Alignment Length:	521	Identity:	180/521 - (34%)
Similarity:	277/521 - (53%)	Gaps:	63/521 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 FLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLL 359
            |..:.|.:|.:...:...|.|||.||.:.|:.:||||.:...|:.:...|.|.|::||||:||::
Worm     7 FFTLILLVSIERVYSSDEEYRLLKDLREGYDPVERPVADHRKPVNVKLRLILQQLVDVDERNQVI 71

  Fly   360 VTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGS 424
            ...||.:..|||..|||:..:||.:..|:||...:||||:|::|||:|.||.::..::||.:||.
Worm    72 TLVVWNQYTWNDYKLRWSPEEYGNITTLQIPHGTLWKPDILLFNSANEHFDASFPVHMVVSSNGD 136

  Fly   425 CLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDE--TGG---DISSYVLNG 484
            .|:.||||...:|.:.:||||:|.|.|.:||||||| |.:||||:.|.  ..|   |:..|:.||
Worm   137 VLFAPPGIVSFSCSLSMTWFPYDQQVCYLKFGSWTY-GKKLDLQIDDSDLPDGHKMDLQYYIPNG 200

  Fly   485 EWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSG 549
            |::||..|..|....:  ..|.|:::.|.:.::|||:||..|.|:|.:||:...:||||:||:.|
Worm   201 EFDLLATPAFRKSTTF--LDETYVELYFHMHLKRRTMYYGLNWIVPSILISLSNILGFTMPPECG 263

  Fly   550 EKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADT 614
            ||::|.:|..||:.|||.||:|..|.||:::|::..:|:..:.::..|:.::::|:|...|:..|
Worm   264 EKITLQITNFLSVMVFLAMVSEVAPPTSESIPIIAAFFSLSIVILGLSICASLIIVNIFFRHPKT 328

  Fly   615 HEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLAN 679
            |.|.:|.|.|||.||||.|.||||..        |.|.....|.|    :|.|.....:| ||.|
Worm   329 HRMGDWTRYVFLEWLPWFLLMSRPEH--------TFCRPRREEEK----NDEEAGGDGTK-LLEN 380

  Fly   680 VLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYE 744
                                ..|.|                      .|..:.:...:..||...
Worm   381 --------------------QQHQP----------------------RPRLLVNSQLVMDSTVPY 403

  Fly   745 LGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAPHIIVSX 809
            |..|:..::....:|..|:|..:...:|:|.|||:|||.|.:||......|..:....|::...
Worm   404 LEEIIGYLKVFKAKLDDDEEEEEEILNWRFMAMVIDRLSLFLFTGLIFGTTALIFAFCPNLFTDS 468

  Fly   810 P 810
            |
Worm   469 P 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	175/493 (35%)
eat-2	NP_496959.1	LIC	3..459	CDD:273305	178/509 (35%)
		Neur_chan_LBD	25..234	CDD:280998	89/211 (42%)
		Neur_chan_memb	242..456	CDD:280999	81/268 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880