Protein Alignment nAChRalpha5 and eat-2

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_496959.1
• Gene: eat-2 / 175072
• WormBaseID: WBGene00001133
• Length: 474
• Species: Caenorhabditis elegans
• Alignment Length: 521
• Identity: 180/521 - (34%)
• Similarity: 277/521 - (53%)
• Gaps: 63/521 - (12%)

  Fly   295 FLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLL 359
            |..:.|.:|.:...:...|.|||.||.:.|:.:||||.:...|:.:...|.|.|::||||:||::
 Worm     7 FFTLILLVSIERVYSSDEEYRLLKDLREGYDPVERPVADHRKPVNVKLRLILQQLVDVDERNQVI 71

  Fly   360 VTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGS 424
            ...||.:..|||..|||:..:||.:..|:||...:||||:|::|||:|.||.::..::||.:||.
 Worm    72 TLVVWNQYTWNDYKLRWSPEEYGNITTLQIPHGTLWKPDILLFNSANEHFDASFPVHMVVSSNGD 136

  Fly   425 CLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDE--TGG---DISSYVLNG 484
            .|:.||||...:|.:.:||||:|.|.|.:||||||| |.:||||:.|.  ..|   |:..|:.||
 Worm   137 VLFAPPGIVSFSCSLSMTWFPYDQQVCYLKFGSWTY-GKKLDLQIDDSDLPDGHKMDLQYYIPNG 200

  Fly   485 EWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSG 549
            |::||..|..|....:  ..|.|:::.|.:.::|||:||..|.|:|.:||:...:||||:||:.|
 Worm   201 EFDLLATPAFRKSTTF--LDETYVELYFHMHLKRRTMYYGLNWIVPSILISLSNILGFTMPPECG 263

  Fly   550 EKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADT 614
            ||::|.:|..||:.|||.||:|..|.||:::|::..:|:..:.::..|:.::::|:|...|:..|
 Worm   264 EKITLQITNFLSVMVFLAMVSEVAPPTSESIPIIAAFFSLSIVILGLSICASLIIVNIFFRHPKT 328

  Fly   615 HEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLAN 679
            |.|.:|.|.|||.||||.|.||||..        |.|.....|.|    :|.|.....:| ||.|
 Worm   329 HRMGDWTRYVFLEWLPWFLLMSRPEH--------TFCRPRREEEK----NDEEAGGDGTK-LLEN 380

  Fly   680 VLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYE 744
                                ..|.|                      .|..:.:...:..||...
 Worm   381 --------------------QQHQP----------------------RPRLLVNSQLVMDSTVPY 403

  Fly   745 LGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAPHIIVSX 809
            |..|:..::....:|..|:|..:...:|:|.|||:|||.|.:||......|..:....|::...
 Worm   404 LEEIIGYLKVFKAKLDDDEEEEEEILNWRFMAMVIDRLSLFLFTGLIFGTTALIFAFCPNLFTDS 468

  Fly   810 P 810
            |
 Worm   469 P 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	175/493 (35%)
eat-2	NP_496959.1	LIC	3..459	CDD:455710	178/509 (35%)
		Neur_chan_LBD	25..234	CDD:460752	89/211 (42%)