Protein Alignment nAChRalpha5 and lgc-20

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_496423.1
• Gene: lgc-20 / 174733
• WormBaseID: WBGene00007191
• Length: 454
• Species: Caenorhabditis elegans
• Alignment Length: 272
• Identity: 55/272 - (20%)
• Similarity: 100/272 - (36%)
• Gaps: 77/272 - (28%)

  Fly   253 ISYLGSFAAQLRSSSSS-------SSNSSNSGNSSSTQILNGLNKHSWIFLLIYLNLSAKVCLAG 310
            :|:|..|.|.|...:|.       :.|.:|..        :|.::|    .|.|..|:.:
 Worm     1 MSFLVLFGALLLIQTSEQMVQCRYTKNLTNRA--------DGGDEH----CLFYYLLNKE----- 48

  Fly   311 YHEKRLLHDL-LDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVW--LKLEWNDM 372
            |.:...:|.| ..|.|         ||.:.::....|::.::: .|......||:  :.|.|.|.
 Worm    49 YEKSGSVHSLSAYPPN---------SDEMTITIENVLVKYVEL-VKGSSYQFNVFGDIYLNWKDE 103

  Fly   373 NLRWN-TSDYGGVKDLRI-PPHRIWKPDVLMYNSADEG------------FDGTYQTNVVVRNNG 423
            .::|: ..::...:.|.| ....||.|.|:.:....||            .|||....:..:
 Worm   104 RMKWDKKGEFENYEHLYIFNSSAIWTPHVIDHTLCSEGGCSYSVDDVDIYDDGTIYARIQFK--- 165

  Fly   424 SCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNG-EWE 487
                     :.::|.:|...||.:|..|.:.|.::             |...:.::.||.| |.|
 Worm   166 ---------YLASCTVDYRKFPEEDDSCCIFFTAF-------------EPNVEQTTLVLEGKEKE 208

  Fly   488 LLGVPGKRNEIY 499
            .:..|....:||
 Worm   209 KMNRPVYAQKIY 220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	41/205 (20%)
lgc-20	NP_496423.1	LGIC_ECD	68..>206	CDD:355788	30/163 (18%)
		Cys-loop	170..184	CDD:349787	5/13 (38%)
		DUF2070	274..>365	CDD:391572

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910