Protein Alignment nAChRalpha5 and acr-7

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_495647.1
• Gene: acr-7 / 174262
• WormBaseID: WBGene00000046
• Length: 538
• Species: Caenorhabditis elegans
• Alignment Length: 542
• Identity: 207/542 - (38%)
• Similarity: 293/542 - (54%)
• Gaps: 54/542 - (9%)

  Fly   295 FLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLL 359
            ||:::...:.:   ....|.:|..|||..|:.|.|||.|....|.::..:.:.|::.||.|:|::
 Worm    16 FLIVFNGFTVE---GSKKEAQLYRDLLTNYSYLVRPVRNPKKALTVTMKVFIQQVLLVDAKHQMI 77

  Fly   360 VTNVWLKLEWNDMNLRWNTSDYGGVKDLRIP-PHRIWKPDVLMYN----SADEGFDGTYQTNVVV 419
            ..|.|||..|.|..||||..||..:..:|.. ..:||:||:|:||    ...|.||.||:||.|.
 Worm    78 EVNAWLKYIWTDFRLRWNPLDYENITSVRFQGEDQIWQPDILLYNRYIEDEQESFDITYKTNAVA 142

  Fly   420 RNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQ----DETGGDISSY 480
            .::|...::||||||.:||:|||.||||:|.|.||||||||.||.|||:|.    .|...|:|:|
 Worm   143 YSDGVINWIPPGIFKLSCKMDITLFPFDEQICFMKFGSWTYHGFALDLRLDVVKGQEPSADLSTY 207

  Fly   481 VLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLP 545
            :.||||.||..|.:|.|.:|.||.|||..:.|.:.:||||.||.||:::|.:|::.|:||.|.||
 Worm   208 ITNGEWHLLSAPARREEKFYKCCKEPYPTVKFYLHLRRRTFYYVFNVVLPTLLVSFMSLLAFCLP 272

  Fly   546 -PDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHH 609
             .|..||:.|..|||||:..||.:::|..|.||:||||||.:|:.:.|:||.|...|||:||..:
 Worm   273 ATDLSEKIGLQTTILLSVCFFLTILSEMTPTTSEAVPLLGVFFSALTFIVAMSTTFTILVLNIRY 337

  Fly   610 RNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPT-TPCSDTSSERKHQILSDVELKERSS 673
            |....|.:|...|.:||..|||::.|.||..    :|.. :...|:|:::..|...:.||
 Worm   338 RQITNHYLSPMFRSIFLECLPWLMMMKRPDH----KFRRGSSYRDSSADQCVQCAKNAEL----- 393

  Fly   674 KSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIG---PIGSTRMPDAVTHH- 734
            ||:|... |.......|.....|..||..|    |.|   ||...|.   .|......:..||.
 Worm   394 KSILRGT-DNQQQIETNTFYPFPTETLSLN----RKV---GDGLFIQRRCQIHEEARSEKFTHGM 450

  Fly   735 -TCIKSSTE---------------YELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLC 783
             .|.||..|               ||  :::.::..|..::....:..||.::|||||..|||.|
 Worm   451 LACEKSLRENGSELANILVTILKMYE--VMVSQVERIRKRIALKRKRKDIQDEWKFAAQAVDRFC 513

  Fly   784 LIIFTMFTILATIAVLLSAPHI 805
            |||||:..|:... :.::.|.|
 Worm   514 LIIFTIVFIICCF-IFVAIPPI 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	203/519 (39%)
acr-7	NP_495647.1	LIC	28..524	CDD:273305	203/514 (39%)
		Neur_chan_LBD	31..247	CDD:280998	99/215 (46%)
		Neur_chan_memb	254..524	CDD:280999	98/288 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H593
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880