Protein Alignment nAChRalpha5 and unc-29

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_492399.1
• Gene: unc-29 / 172703
• WormBaseID: WBGene00006765
• Length: 493
• Species: Caenorhabditis elegans
• Alignment Length: 529
• Identity: 177/529 - (33%)
• Similarity: 292/529 - (55%)
• Gaps: 75/529 - (14%)

  Fly   289 NKHSWIFLL---IYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESD-PLQLSFGLTLMQI 349
            |:.|||.:|   |:| :......|...|:||:.|:...||:|.:||.|.|: ||.:...|.|:.:
 Worm     4 NRLSWILVLSVVIFL-VIINTINASDDEERLMVDVFRGYNSLIQPVRNSSELPLIVKMALQLVLL 67

  Fly   350 IDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQ 414
            |:||||:|::.|||||.|:|:|..::||..:||.:|.:|:.|.::|.||::::|:||..::.::.
 Worm    68 INVDEKDQVMHTNVWLTLQWHDFQMKWNPVNYGEIKQIRVSPDKVWLPDIVLFNNADGNYEVSFM 132

  Fly   415 TNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISS 479
            .|||:.:.|..|:|||.|:||:|.||:.:||||:|.|.:.||||||:..::.|:.......|:|.
 Worm   133 CNVVINHKGDMLWVPPAIYKSSCIIDVEFFPFDEQVCTLVFGSWTYNENEIKLEFVQAELVDVSE 197

  Fly   480 YVLNGEWELLGVP----GKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALL 540
            |..:..|:::.||    .||:.            |.|.:.|||:||:|...||||.||:|.:::.
 Worm   198 YSASSIWDVIDVPASLVNKRSR------------IEFQVRIRRKTLFYTVVLIIPTVLMAFLSMA 250

  Fly   541 GFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILIL 605
            .|.||.|||||::|.:::|||:.|||.:|::.:|.||..:||:..|......:...:::.|::|:
 Worm   251 VFFLPTDSGEKITLTISVLLSIVVFLLLVSKILPPTSSTIPLMAKYLLLTFVLNVITILVTVIII 315

  Fly   606 NYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKE 670
            |.:.|...||.|.:|:|:|||.:||.::.|.||              .::|||.         ..
 Worm   316 NVYFRGPRTHRMPQWVRVVFLQFLPKLVCMKRP--------------KSASERS---------AV 357

  Fly   671 RSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHT 735
            ||..:.|..|                 |....:|:.:..:....||      .:|.:.:..::.|
 Worm   358 RSGMAQLPGV-----------------GQFTLSPSAHHPLCPSADD------RTTTIRNTASNET 399

  Fly   736 CIKSSTEYELGL----ILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATI 796
                |..|.|..    .:..|.:||:.|::|::.....:|||:.||::|||.|.:|...|:..|.
 Worm   400 ----SAYYPLSTDALRAIDAIEYITEHLKRDEQHKSFRDDWKYVAMIIDRLLLYVFFGITVGGTC 460

  Fly   797 AVLLSAPHI 805
            .:|.||||:
 Worm   461 GILFSAPHV 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	165/497 (33%)
unc-29	NP_492399.1	LIC	6..466	CDD:273305	172/522 (33%)
		Neur_chan_LBD	30..230	CDD:280998	82/211 (39%)
		Neur_chan_memb	237..462	CDD:280999	79/274 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910