Protein Alignment nAChRalpha5 and unc-38

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_491472.1
• Gene: unc-38 / 172105
• WormBaseID: WBGene00006774
• Length: 511
• Species: Caenorhabditis elegans
• Alignment Length: 536
• Identity: 189/536 - (35%)
• Similarity: 281/536 - (52%)
• Gaps: 79/536 - (14%)

  Fly   293 WIFLLIYLNLSAKVCLAGYHE--KRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEK 355
            |:|||:.|...:.:.|...:|  |||..||:..||...||..:.:.||.:...|.|.|||||.|.
 Worm     5 WLFLLLLLFCISFIKLTEGNEDAKRLYDDLMVNYNRHRRPSTSPNKPLTIKLKLRLSQIIDVHEI 69

  Fly   356 NQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVR 420
            :|::..:||||..|.|..|.|:..:||||..|.:|...||.||:::||:||..::.|..|...:.
 Worm    70 DQIMTCSVWLKQTWIDRKLSWDPVNYGGVNVLYVPYEMIWVPDIVLYNNADSNYNITISTKATLH 134

  Fly   421 NNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQD-------------- 471
            ..|...:.||.||||.|:||:.|||||:|:|.:||||||:....|.::|.:
 Worm   135 YTGEVTWEPPAIFKSMCQIDVRWFPFDEQQCHLKFGSWTFSENLLSVELNEPSLRYEEEIDEKGI 199

  Fly   472 -------ETGGDISSYVLNGEWELLG-VPGKRNEIYYNCCPE-PYIDITFAIIIRRRTLYYFFNL 527
                   |.|.|:|.|..:.||:::. |..:|.:.|.:|||: .|||:|:.:.:||:.|:|..||
 Worm   200 IDNVTVAEDGIDLSDYYPSVEWDIMSRVAKRRAKNYPSCCPQSAYIDVTYYLQLRRKPLFYTVNL 264

  Fly   528 IIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMF 592
            :.|||.|:.:.:|.|.||.|||||::|.::||::||:|..::.|.:||||..:||:|.|....|.
 Worm   265 VFPCVGISFLTILVFYLPSDSGEKVTLCISILVALTIFFLLLTEIIPATSITLPLIGKYLLFTMV 329

  Fly   593 MVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSE 657
            ||..|||.|::.||.|.|...||.|..|::.|||.|||.:|.|.||             .|...|
 Worm   330 MVTLSVVVTVISLNLHFRTPTTHLMPNWVKKVFLKWLPKLLFMRRP-------------IDDYEE 381

  Fly   658 RKHQILSDVELKERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPI 722
            :     .|.:.|.:..|..|:.......:..:|.|..|...|:  ...:|..           |:
 Worm   382 K-----FDDKKKPKDGKIALSVHAHRVSNVGNNIRNATIDDTI--QKMYYSP-----------PV 428

  Fly   723 GSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIF 787
                          :|:         .:.|.||.:.|:|.|..:.|..|||:.|||:|||.|:||
 Worm   429 --------------VKA---------FENICFIAELLKKKDRDDKIDEDWKYVAMVLDRLFLLIF 470

  Fly   788 TMFTILATIAVLLSAP 803
            ::...:.|:.:||.||
 Worm   471 SIACFVGTVIILLRAP 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	181/513 (35%)
unc-38	NP_491472.1	LGIC_ECD_nAChR_proto_alpha-like	26..259	CDD:349832	88/232 (38%)
		Cys-loop	151..165	CDD:349832	9/13 (69%)
		Neur_chan_memb	264..481	CDD:460753	87/270 (32%)