Protein Alignment nAChRalpha5 and Chrna2

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_596911.1
• Gene: Chrna2 / 170945
• RGDID: 621533
• Length: 511
• Species: Rattus norvegicus
• Alignment Length: 516
• Identity: 199/516 - (38%)
• Similarity: 292/516 - (56%)
• Gaps: 37/516 - (7%)

  Fly   293 WIFLLIYLNLSAKVCLAGYH---EKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDE 354
            |..||:    .|.:...|.|   |.||...|...||...|||.|.||.:.:.|||::.|:|||||
  Rat    17 WCLLLV----PAVLTQQGSHTHAEDRLFKHLFGGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDE 77

  Fly   355 KNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVV 419
            |||::.||||||.||||..|||:.:::|.|..||:|...||.||:::||:||..|..|:.|...:
  Rat    78 KNQMMTTNVWLKQEWNDYKLRWDPAEFGNVTSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHL 142

  Fly   420 RNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNG 484
            ...|:..:|||.|:||:|.||:|:||||.|.|:|||||||||..::||:..:.| .|:..|..:|
  Rat   143 FFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMERT-VDLKDYWESG 206

  Fly   485 EWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSG 549
            ||.::...|..|...|:||.|.|.|:|:..:|||..|:|..||||||:||:.:.:|.|.||.:.|
  Rat   207 EWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECG 271

  Fly   550 EKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADT 614
            ||::|.:::||||||||.::.|.:|:||..:||:|.|....|..|..|:|.|:.:||.|||:..|
  Rat   272 EKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPST 336

  Fly   615 HEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTS-SERKHQILSDVELKERSSKSLLA 678
            |.|..|:|:..|..:|..|.|:||..|  :|...:|  |.. |...|.:.::::..||....
  Rat   337 HNMPNWVRVALLGRVPRWLMMNRPLPP--MELHGSP--DLKLSPSYHWLETNMDAGEREETE--- 394

  Fly   679 NVLDIDDDFRHNC----RPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKS 739
              .:.:::..:.|    .|.:..|.|          ||.|     |.......|:..|.....:.
  Rat   395 --EEEEEEDENICVCAGLPDSSMGVL----------YGHG-----GLHLRAMEPETKTPSQASEI 442

  Fly   740 STEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLL 800
            ....::...|:.:.:|.|:||.:|..:.:..|||:.||||||:.|.:|.:...|.||.:.|
  Rat   443 LLSPQIQKALEGVHYIADRLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGLFL 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	193/493 (39%)
Chrna2	NP_596911.1	LIC	35..504	CDD:455710	193/494 (39%)
		LGIC_ECD_nAChR_A2	36..242	CDD:349816	99/206 (48%)
		Cys-loop	160..174	CDD:349816	9/13 (69%)