DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha5 and HTR3C

DIOPT Version :9

Sequence 1:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_570126.2	Gene:	HTR3C / 170572	HGNCID:	24003	Length:	447	Species:	Homo sapiens

Alignment Length:	334	Identity:	99/334 - (29%)
Similarity:	149/334 - (44%)	Gaps:	35/334 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 RPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHR 393
            ||..|.|.|.:::...||..|:.||.:.|||.:.:|:.|.|::..:.||..:..|:..|.:....
Human    55 RPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAEN 119

  Fly   394 IWKPDVLMYNSADEGFDGTYQ-TNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGS 457
            :|.||:.:..|.|  .|.|.. ....:.:.|...|..|....|.|.:||.:||||.|.|...|.|
Human   120 LWLPDIFIVESMD--VDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSS 182

  Fly   458 WTY--DGFQLDLQLQDETGGDISSYVL--NGEWELLGV------PGKRNEIYYNCCPEPYIDITF 512
            :.|  |...|.:..:.....|.|..|:  .|||||||:      ....|.:        |..|.|
Human   183 FLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMGNNL--------YDQIMF 239

  Fly   513 AIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATS 577
            .:.||||...|..||::|...:.::..|.|.||.:|..:....:|:||...|||.|:.:.:||:
Human   240 YVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLLPAS- 303

  Fly   578 DAVPLLGTYFN-CIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRP 641
             ..||:..||. |:..||.|.:.:..:....|........|..|:..:       :|..:.|||.
Human   304 -GTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSL-------LLHCTSPGRC 360

  Fly   642 LILEFPTTP 650
            .    ||.|
Human   361 C----PTAP 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	99/334 (30%)
HTR3C	NP_570126.2	Neur_chan_LBD	43..445	CDD:332142	99/334 (30%)
HTR3C	NP_570126.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..405
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910