Protein Alignment nAChRalpha5 and Htr3a

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_038589.2
• Gene: Htr3a / 15561
• MGIID: 96282
• Length: 489
• Species: Mus musculus
• Alignment Length: 505
• Identity: 151/505 - (29%)
• Similarity: 233/505 - (46%)
• Gaps: 73/505 - (14%)

  Fly   315 RLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTS 379
            ||...||..|....|||.:...|..:|..:.:..|::||||||:|.|.:|.:..|.|..|:|...
Mouse    41 RLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPE 105

  Fly   380 DYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWF 444
            |:..|..|.||...||.||:|:....|.|..... ..|.|.:.|......|....:.|.:||..|
Mouse   106 DFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNI-PYVYVHHRGEVQNYKPLQLVTACSLDIYNF 169

  Fly   445 PFDDQRCEMKFGSWTYDGFQLDLQL---QDETGGDISSYVLNGEWELLGVPGKRNEIYYNCCPEP 506
            |||.|.|.:.|.||.:....:::.|   .:|...|.|.::..||||||.|..:..|...: ....
Mouse   170 PFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSID-ISNS 233

  Fly   507 YIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAE 571
            |.::.|.:|||||.|:|..:|::|.:.:..:.::||.|||||||::|..:|:||..:|||.:|::
Mouse   234 YAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSD 298

  Fly   572 TMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMS 636
            |:|||:...||:|.||...|.::..|:..||.|:...|:......:.:|:|.:.|..:.|||.:.
Mouse   299 TLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILCLG 363

  Fly   637 RPGRPLILEFPTT-------PCSDTSSERKHQILSDVELKERSSKSLLANVLDIDDDFRHNCRPM 694
            .  :|:....|.|       .||.:                           |:.....::|..:
Mouse   364 E--QPMAHRPPATFQANKTDDCSGS---------------------------DLLPAMGNHCSHV 399

  Fly   695 TPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYELGL--ILKEIRFITD 757
              ||  |.:  ..:|..|:|     .|:...|               |..|.:  :|:|:..|..
Mouse   400 --GG--PQD--LEKTPRGRG-----SPLPPPR---------------EASLAVRGLLQELSSIRH 438

  Fly   758 QLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILA---TIAVLLSAPH 804
            .|.|.||..::|.||.....|:|||...|: :..:||   |:..|.|..|
Mouse   439 FLEKRDEMREVARDWLRVGYVLDRLLFRIY-LLAVLAYSITLVTLWSIWH 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	149/501 (30%)
Htr3a	NP_038589.2	LIC	5..483	CDD:273305	148/499 (30%)
		HA-stretch	425..461		11/35 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910