Protein Alignment nAChRalpha5 and nAChRalpha6

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: XP_061502417.1
• Gene: nAChRalpha6 / 1269406
• VectorBaseID: AGAMI1_002766
• Length: 509
• Species: Anopheles gambiae
• Alignment Length: 537
• Identity: 347/537 - (64%)
• Similarity: 401/537 - (74%)
• Gaps: 58/537 - (10%)

  Fly   293 WIFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDV----- 352
            ::.:|..|.:..|..|.|.||||||::||..||||||||.||||||::.|||||.|||||
Mosquito     8 YLIVLCLLVIYIKDSLQGPHEKRLLNNLLATYNTLERPVANESDPLEVKFGLTLQQIIDVDEKNQ 72

  Fly   353 ----------DEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADE 407
                      |||||||:||:||.|||||.|||||.|:||||:||||.|:::|||||||||||||
Mosquito    73 ILTTNAWLNLDEKNQLLITNIWLSLEWNDYNLRWNDSEYGGVRDLRITPNKLWKPDVLMYNSADE 137

  Fly   408 GFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDE 472
            ||||||.||:||:|||||||||||||||||||||||||||||.||||||||||||.||||.|..:
Mosquito   138 GFDGTYHTNIVVKNNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLILNSD 202

  Fly   473 TGGDISSYVLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASM 537
            .|||:|.::.||||.|:|:|||:|.|.|.||||||:||||.|.|||||||||||||:|||||:||
Mosquito   203 DGGDLSDFITNGEWYLIGMPGKKNTITYQCCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSM 267

  Fly   538 ALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTI 602
            |||||||||||||||:||||||||||||||:||||:|..|||:|||||||||||||||||||.|:
Mosquito   268 ALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTV 332

  Fly   603 LILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILS--- 664
            ::||||||.||.|||..||:.|||.||||||||.||||.:              .||..|||
Mosquito   333 VVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKI--------------TRKTIILSNRM 383

  Fly   665 -DVELKERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGS---T 725
             ::|||||||||||||||||||||||.|                     .|..||...||.   |
Mosquito   384 KELELKERSSKSLLANVLDIDDDFRHPC---------------------SGISGSTTAIGGSVFT 427

  Fly   726 RMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMF 790
            |: ..|.........:..:|..||||::|||::::|.||..::.:|||||||||||.||.:||:|
Mosquito   428 RL-TTVEEQNVSSGCSHKDLHHILKELQFITNRMKKADEEQELISDWKFAAMVVDRFCLFVFTLF 491

  Fly   791 TILATIAVLLSAPHIIV 807
            ||:||:.||||||||||
Mosquito   492 TIIATVTVLLSAPHIIV 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	334/510 (65%)
nAChRalpha6	XP_061502417.1	None