Protein Alignment nAChRalpha5 and CHRNG

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_005190.4
• Gene: CHRNG / 1146
• HGNCID: 1967
• Length: 517
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 166/548 - (30%)
• Similarity: 259/548 - (47%)
• Gaps: 101/548 - (18%)

  Fly   296 LLIYLNLSAKVCLAGY---HEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQ 357
            ||:.|.|:  |||...   .|:|||.||:..|:...||...:||.:.:|..|||..:|.::|:.:
Human     8 LLLLLLLA--VCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREE 70

  Fly   358 LLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNN 422
            .|.||||::::|.|..|||:..||.|:..||:|...:|:||:::.|:.|..|:.....||:|..:
Human    71 ALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPD 135

  Fly   423 GSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGG-------DISSY 480
            |...::||.||:|.|.|.:|:||||.|.|.:.|.|.||...::||||..|.|.       |..::
Human   136 GCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDPEAF 200

  Fly   481 VLNGEWELLGVPGKRNEIYYNCCPEP---YIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGF 542
            ..||||.:...|.|.  :.....|..   :..:.|.::|:|:.|:|..|:|.|||||:|:|:|..
Human   201 TENGEWAIQHRPAKM--LLDPAAPAQEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIH 263

  Fly   543 TLPPDS-GEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILN 606
            .||..: |:|.::.:.:||:.||||.:||:.:|.||.||||:..|...::.:....||:.:::||
Human   264 FLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVVLN 328

  Fly   607 YHHRNADTHEMSEWIRIVFLCWLPWILRMS-RPGRPLILEFPTTPCSDTSSERKHQILSDVELKE 670
            ...|:..||.|:..:|.|||..||.:|||. ||..|..::       ||.|          .|:.
Human   329 VSLRSPHTHSMARGVRKVFLRLLPQLLRMHVRPLAPAAVQ-------DTQS----------RLQN 376

  Fly   671 RSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQG------DDGSIGP-------I 722
            .||...:....::             ...||.:...::....||      :....||       .
Human   377 GSSGWSITTGEEV-------------ALCLPRSELLFQQWQRQGLVAAALEKLEKGPELGLSQFC 428

  Fly   723 GSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIA-------------NDWKF 774
            ||.:.. |.....|:::                         ||.||             .:|..
Human   429 GSLKQA-APAIQACVEA-------------------------CNLIACARHQQSHFDNGNEEWFL 467

  Fly   775 AAMVVDRLCLIIFTMFTILATIAVLLSA 802
            ...|:||:|.:......|..|..:.|.|
Human   468 VGRVLDRVCFLAMLSLFICGTAGIFLMA 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	158/526 (30%)
CHRNG	NP_005190.4	LGIC_ECD_nAChR_G	49..241	CDD:349830	68/193 (35%)
		Neur_chan_memb	248..492	CDD:397193	76/299 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910