Protein Alignment nAChRalpha5 and CHRNE

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_000071.1
• Gene: CHRNE / 1145
• HGNCID: 1966
• Length: 493
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 144/516 - (27%)
• Similarity: 249/516 - (48%)
• Gaps: 69/516 - (13%)

  Fly   313 EKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWN 377
            |.||.|.|.:.|:...|||....|.:.:|..:||..:|.::||.:.|.|:||:.::|.|..|.::
Human    24 ELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYS 88

  Fly   378 TSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDIT 442
            ..|:||::.||:|...:|.|::::.|:.|..|...|..||:|...||..::||.|::|.|.:::|
Human    89 KDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVT 153

  Fly   443 WFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGG--------DISSYVLNGEWELLGVPGKRNEIY 499
            :||||.|.|.:.|.|.||:..:::.....:..|        |..:|..||||.:...||.....:
Human   154 YFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHH 218

  Fly   500 YNCCPEP-YIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDS-GEKLSLGVTILLSL 562
            ......| ..|:.:::||||:.|:|..|:|:|||||:.:.||.:.||..: |:|.::.:.:||:.
Human   219 GGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQ 283

  Fly   563 TVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLC 627
            ||||.::|:.:|.||.:|||||.:...:|.:....|::.:::||...|...||.||..:|.|.|.
Human   284 TVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLE 348

  Fly   628 WLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQI---LSDVELKERSSKSLLANVLDIDDDFRH 689
            .||.:|....|        |..|.:.:...|...:   |...||..:..:|.|     :.:..||
Human   349 LLPRLLGSPPP--------PEAPRAASPPRRASSVGLLLRAEELILKKPRSEL-----VFEGQRH 400

  Fly   690 NCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRF 754
            .....|        .||.:::      |:..|                      |:...:..:.|
Human   401 RQGTWT--------AAFCQSL------GAAAP----------------------EVRCCVDAVNF 429

  Fly   755 ITDQLRKDDECNDIANDWKFAAMVVDRLC----LIIFTMFTILATIAVLLSAPHIIVSXPY 811
            :.:..|..:...:..:||......:|.:|    |::|::.:.|..:....:.   :...||
Human   430 VAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGAYFNR---VPDLPY 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	142/505 (28%)
CHRNE	NP_000071.1	LGIC_ECD_nAChR_E	49..239	CDD:349831	60/189 (32%)
		Cys-loop	148..162	CDD:349831	7/13 (54%)
		Neur_chan_memb	247..474	CDD:460753	68/275 (25%)