DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nAChRalpha5 and CHRNE

DIOPT Version :9

Sequence 1:NP_001356885.1 Gene:nAChRalpha5 / 34826 FlyBaseID:FBgn0028875 Length:837 Species:Drosophila melanogaster
Sequence 2:NP_000071.1 Gene:CHRNE / 1145 HGNCID:1966 Length:493 Species:Homo sapiens


Alignment Length:515 Identity:144/515 - (27%)
Similarity:249/515 - (48%) Gaps:67/515 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   313 EKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWN 377
            |.||.|.|.:.|:...|||....|.:.:|..:||..:|.::||.:.|.|:||:.::|.|..|.::
Human    24 ELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYS 88

  Fly   378 TSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDIT 442
            ..|:||::.||:|...:|.|::::.|:.|..|...|..||:|...||..::||.|::|.|.:::|
Human    89 KDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVT 153

  Fly   443 WFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGG--------DISSYVLNGEWELLGVPGKRNEIY 499
            :||||.|.|.:.|.|.||:..:::.....:..|        |..:|..||||.:...||.....:
Human   154 YFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHH 218

  Fly   500 YNCCPEP-YIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDS-GEKLSLGVTILLSL 562
            ......| ..|:.:::||||:.|:|..|:|:|||||:.:.||.:.||..: |:|.::.:.:||:.
Human   219 GGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQ 283

  Fly   563 TVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLC 627
            ||||.::|:.:|.||.:|||||.:...:|.:....|::.:::||...|...||.||..:|.|.|.
Human   284 TVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLE 348

  Fly   628 WLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANVLD--IDDDFRHN 690
            .||.:|....|        |..|.:.:...|    .|.|.|..|:.:.:|.....  :.:..||.
Human   349 LLPRLLGSPPP--------PEAPRAASPPRR----ASSVGLLLRAEELILKKPRSELVFEGQRHR 401

  Fly   691 CRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFI 755
            ....|        .||.:::      |:..|                      |:...:..:.|:
Human   402 QGTWT--------AAFCQSL------GAAAP----------------------EVRCCVDAVNFV 430

  Fly   756 TDQLRKDDECNDIANDWKFAAMVVDRLC----LIIFTMFTILATIAVLLSAPHIIVSXPY 811
            .:..|..:...:..:||......:|.:|    |::|::.:.|..:....:.   :.. ||
Human   431 AESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGAYFNR---VPDLPY 487

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha5NP_001356885.1 LIC 313..802 CDD:273305 142/504 (28%)
CHRNENP_000071.1 LIC 21..475 CDD:273305 142/498 (29%)
Neur_chan_LBD 24..240 CDD:280998 71/215 (33%)
Neur_chan_memb 247..474 CDD:280999 68/274 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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