Protein Alignment nAChRalpha5 and Chrng

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: XP_006529141.1
• Gene: Chrng / 11449
• MGIID: 87895
• Length: 541
• Species: Mus musculus
• Alignment Length: 525
• Identity: 157/525 - (29%)
• Similarity: 253/525 - (48%)
• Gaps: 88/525 - (16%)

  Fly   313 EKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWN 377
            |:|||.||:..|:...||...:||.:.:|..|||..:|.::|:.:.|.||||::::|.|..|||:
Mouse    48 EERLLADLMRNYDPHLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWD 112

  Fly   378 TSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDIT 442
            ..||.|:..||:|...:|:||:::.|:.|..|:.....||:|..:|...::||.||:|:|.|.:|
Mouse   113 PKDYEGLWILRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRSSCSISVT 177

  Fly   443 WFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGG-------DISSYVLNGEWELLGVPGKRNEIYY 500
            :||||.|.|.:.|.|.||...:::|||..|.|.       |..::..||||.:...|.|.  :..
Mouse   178 YFPFDWQNCSLVFQSQTYSTSEINLQLSQEDGQAIEWIFIDPEAFTENGEWAIRHRPAKM--LLD 240

  Fly   501 NCCPEP---YIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDS-GEKLSLGVTILLS 561
            :..|..   :..:.|.::|:|:.|:|..|:|.|||||:|:|:|.:.||..: |:|.::...:||:
Mouse   241 SVAPAEEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIYFLPAKAGGQKCTVATNVLLA 305

  Fly   562 LTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFL 626
            .||||.:||:.:|.||.||||:..|...:|.:....||:::::||...|:..||.|:..:|.|||
Mouse   306 QTVFLFLVAKKVPETSQAVPLISKYLTFLMVVTILIVVNSVVVLNVSLRSPHTHSMARGVRKVFL 370

  Fly   627 CWLPWILRMS-RPGRPLILEFPTTPCSDTSSE------RKHQIL----SDVELKERSSKSLLANV 680
            ..||.:|||. ||..|..::.......:.||.      |:...|    |::..::|....|:..|
Mouse   371 RLLPQLLRMHVRPLAPAAVQDARFRLQNGSSSGWPIMAREEGDLCLPRSELLFRQRQRNGLVQAV 435

  Fly   681 LDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYEL 745
            |:          .:..|..:..:..|               .||.:...... ..|:
Mouse   436 LE----------KLENGPEVRQSQEF---------------CGSLKQASPAI-QACV-------- 466

  Fly   746 GLILKEIRFITDQLRKDDECNDIA-------------NDWKFAAMVVDRLCLIIFTMFTILATIA 797
                             |.||.:|             .:|.....|:||:|.:......|..|..
Mouse   467 -----------------DACNLMARARRQQSHFDSGNEEWLLVGRVLDRVCFLAMLSLFICGTAG 514

  Fly   798 VLLSA 802
            :.|.|
Mouse   515 IFLMA 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	156/523 (30%)
Chrng	XP_006529141.1	LGIC_ECD_nAChR_G	71..263	CDD:349830	67/193 (35%)
		Neur_chan_memb	270..515	CDD:367256	75/295 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910