Protein Alignment nAChRalpha5 and Chrnd

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_067611.2
• Gene: Chrnd / 11447
• MGIID: 87893
• Length: 520
• Species: Mus musculus
• Alignment Length: 523
• Identity: 160/523 - (30%)
• Similarity: 255/523 - (48%)
• Gaps: 92/523 - (17%)

  Fly   313 EKRLLHDLLDP--YNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLR 375
            |:||:..|.:.  |:...|||..:.|.:.::..|||..:|.:.|..:.|.||||:...|.|..|:
Mouse    28 EQRLIQHLFNEKGYDKDLRPVARKEDKVDVALSLTLSNLISLKEVEETLTTNVWIDHAWVDSRLQ 92

  Fly   376 WNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKID 440
            |:.:|:|.:..||:||..:|.|::::.|:.|..|..:|..||:|.::|...::||.||:|:|.|.
Mouse    93 WDANDFGNITVLRLPPDMVWLPEIVLENNNDGSFQISYACNVLVYDSGYVTWLPPAIFRSSCPIS 157

  Fly   441 ITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGG-----------DISSYVLNGEWELLGVPGK 494
            :|:||||.|.|.:||.|..|...::.|.|:.|...           |...:..|||||::....|
Mouse   158 VTYFPFDWQNCSLKFSSLKYTAKEITLSLKQEEENNRSYPIEWIIIDPEGFTENGEWEIVHRAAK 222

  Fly   495 RNEIYYNCCPEPYI--------DITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEK 551
            .|       .:|.:        |:||.:||||:.|:|..|:::|||||:.|..|.|.||.|.|||
Mouse   223 LN-------VDPSVPMDSTNHQDVTFYLIIRRKPLFYIINILVPCVLISFMINLVFYLPGDCGEK 280

  Fly   552 LSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHE 616
            .|:.:::||:.:|||.::::.:||||.|:||:|.:....|.:|...||..:::||.|.|...||.
Mouse   281 TSVAISVLLAQSVFLLLISKRLPATSMAIPLVGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHV 345

  Fly   617 MSEWIRIVFLCWLPWILRMSRPG------RPLILEFPTTPCSDTSSERKHQILSDV-------EL 668
            :||.::..||..||.:|.||||.      |.||              |:...|..:       .|
Mouse   346 LSEGVKKFFLETLPKLLHMSRPAEEDPGPRALI--------------RRSSSLGYICKAEEYFSL 396

  Fly   669 KERSSKSLLANVLDIDDDFRHN-CRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVT 732
            |.||      :::......||. .|.:|                            :.|.|.|.:
Mouse   397 KSRS------DLMFEKQSERHGLARRLT----------------------------TARRPPASS 427

  Fly   733 HHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIA 797
            ..  ::.....|:...:....||.:.:|..:..|:..::|...|..||||||.:.|...::.|..
Mouse   428 EQ--VQQELFNEMKPAVDGANFIVNHMRDQNSYNEEKDNWNQVARTVDRLCLFVVTPVMVVGTAW 490

  Fly   798 VLL 800
            :.|
Mouse   491 IFL 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	160/523 (31%)
Chrnd	NP_067611.2	LGIC_ECD	29..249	CDD:475126	75/226 (33%)
		Neur_chan_memb	256..492	CDD:460753	80/285 (28%)