Protein Alignment nAChRalpha5 and Chrnb2

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_033732.2
• Gene: Chrnb2 / 11444
• MGIID: 87891
• Length: 501
• Species: Mus musculus
• Alignment Length: 493
• Identity: 188/493 - (38%)
• Similarity: 281/493 - (56%)
• Gaps: 48/493 - (9%)

  Fly   313 EKRLLHDLLDP--YNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLR 375
            |:||:..||||  ||.|.||..|.|:.:.:...::|.|:|.|.|:.|::.|||||..||.|..|.
Mouse    29 EERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLT 93

  Fly   376 WNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKID 440
            |...|:..:|.:|:|...||.|||::||:||..::.::.:|.||..:||..::||.|:||.|||:
Mouse    94 WKPEDFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIE 158

  Fly   441 ITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGKRNEIYYNCCPE 505
            :..||||.|.|.|||.|||||..::||.|:.:. ..:..:..:|||:::.:||:|||   |....
Mouse   159 VKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSDV-ASLDDFTPSGEWDIIALPGRRNE---NPDDS 219

  Fly   506 PYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVA 570
            .|:|||:..||||:.|:|..|||||||||.|:|:|.|.||.|.|||::|.:::||:|||||.:::
Mouse   220 TYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLIS 284

  Fly   571 ETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRM 635
            :.:|.||..|||:|.|....|.:|..|:|:::.:||.|||:..||.|:.|:::|||..||.:|.:
Mouse   285 KIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPTLLFL 349

  Fly   636 SRPGRPLILEFPTTPCSDTSSERKHQILSD-VELKERSSKSLLANVLDIDDDFRHNCRPMTPGGT 699
            .:|                    :|:.... :.|:.|..:...|..|    .||..  |.....|
Mouse   350 QQP--------------------RHRCARQRLRLRRRQREREGAGTL----FFREG--PAADPCT 388

  Fly   700 LPHNPAFYRTVYG--QGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKD 762
            ...|||..:.:.|  |.:..:.| :|.:..|       |.....|...|     :|||.|.:|.:
Mouse   389 CFVNPASMQGLAGAFQAEPAAAG-LGRSMGP-------CSCGLREAVDG-----VRFIADHMRSE 440

  Fly   763 DECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLL 800
            |:...:..|||:.|||:|||.|.||....:..||.:.|
Mouse   441 DDDQSVREDWKYVAMVIDRLFLWIFVFVCVFGTIGMFL 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	188/493 (38%)
Chrnb2	NP_033732.2	LIC	29..478	CDD:455710	187/491 (38%)
		LGIC_ECD_nAChR_B2	31..234	CDD:349826	89/206 (43%)
		Cys-loop	155..169	CDD:349826	8/13 (62%)