Protein Alignment nAChRalpha5 and Chrnb1

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_033731.3
• Gene: Chrnb1 / 11443
• MGIID: 87890
• Length: 501
• Species: Mus musculus
• Alignment Length: 550
• Identity: 166/550 - (30%)
• Similarity: 265/550 - (48%)
• Gaps: 127/550 - (23%)

  Fly   313 EKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWN 377
            |.:|:..|...|::..||.....|.:.:|.||||.|:|.::||::.:.|.|:|.|||.|..|.|:
Mouse    27 EGQLIKKLFSNYDSSVRPAREVGDRVGVSIGLTLAQLISLNEKDEEMSTKVYLDLEWTDYRLSWD 91

  Fly   378 TSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDIT 442
            .:::.|:..|||....:|.|||::.|:.|..||.....||||...||..:.|||:::|:|.|.:|
Mouse    92 PAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDINVVVSFEGSVRWQPPGLYRSSCSIQVT 156

  Fly   443 WFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGD--------ISSYVLNGEWELLGVP------- 492
            :||||.|.|.|.|.|::||..::.|:...:..|:        ..:::.||:||::..|
Mouse   157 YFPFDWQNCTMVFSSYSYDSSEVSLKTGLDPEGEERQEVYIHEGTFIENGQWEIIHKPSRLIQLP 221

  Fly   493 -----GKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKL 552
                 ||...         :.::.|.:||||:.|:|..|:|.||:||..:|:..|.||||:|||:
Mouse   222 GDQRGGKEGH---------HEEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKM 277

  Fly   553 SLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEM 617
            .|.:..||:|||||.::|:.:|.||.|||::..|....|.:|..||:.::::||.|||:..||:|
Mouse   278 GLSIFALLTLTVFLLLLADKVPETSLAVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQM 342

  Fly   618 SEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANVLD 682
            ..|:|.:|:..||..|.:.|| :|               ||.       :|.|
Mouse   343 PFWVRQIFIHKLPPYLGLKRP-KP---------------ERD-------QLPE------------ 372

  Fly   683 IDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSI---------------------------- 719
                              ||:....|:.:|:|.|...
Mouse   373 ------------------PHHSLSPRSGWGRGTDEYFIRKPPSDFLFPKLNRFQPESSAPDLRRF 419

  Fly   720 --GPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRL 782
              ||..:..:|.              ||..::..|.::..||::.::.:.:..||:|.|||||||
Mouse   420 IDGPTRAVGLPQ--------------ELREVISSISYMARQLQEQEDHDALKEDWQFVAMVVDRL 470

  Fly   783 CLIIFTMFTILATIAVLLSAP-HIIVSXPY 811
            .|..|.:||.:.|:.:.|.|. |:... |:
Mouse   471 FLWTFIVFTSVGTLVIFLDATYHLPPPEPF 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	163/538 (30%)
Chrnb1	NP_033731.3	LIC	24..488	CDD:273305	162/536 (30%)
		Neur_chan_LBD	27..245	CDD:280998	75/226 (33%)
		Neur_chan_memb	252..487	CDD:280999	84/301 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..382		10/72 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910