Protein Alignment nAChRalpha5 and Chrna7

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_031416.3
• Gene: Chrna7 / 11441
• MGIID: 99779
• Length: 502
• Species: Mus musculus
• Alignment Length: 522
• Identity: 257/522 - (49%)
• Similarity: 345/522 - (66%)
• Gaps: 48/522 - (9%)

  Fly   298 IYLNLSA---KVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLL 359
            |:|.|:|   .|.|.|..::||..:|:..||.|||||.|:|.||.:.|.|:|:||:|||||||:|
Mouse     8 IWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVL 72

  Fly   360 VTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGS 424
            .||:||::.|.|..|:||.|:|.|||::|.|..:|||||:|:||||||.||.|:.|||:|..:|.
Mouse    73 TTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGH 137

  Fly   425 CLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELL 489
            |.|:|||||||:|.||:.|||||.|:|::|||||:|.|:.||||:|:   .|||||:.||||:|:
Mouse   138 CQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQE---ADISSYIPNGEWDLM 199

  Fly   490 GVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSL 554
            |:||||||.:|.||.|||.|:|:.:.:|||||||..||:||||||:::|||.|.||.|||||:||
Mouse   200 GIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISL 264

  Fly   555 GVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSE 619
            |:|:|||||||:.:|||.||||||:|||:..||...|.:|..|||.|:::|.|||.:.|..:|.:
Mouse   265 GITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPK 329

  Fly   620 WIRIVFLCWLPWILRMSRPG----RPLILEFPTTPCSDTSSERKHQILSDVELKERSS-KSLLAN 679
            |.||:.|.|..|.|||.|||    ||.....|.. ||          |:.|||...:. .:...|
Mouse   330 WTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRR-CS----------LASVELSAGAGPPTSNGN 383

  Fly   680 VLDIDDDFR----HNCRPMTPGGTLPHNPAFYRTVYGQGDDGSI-GPIGSTRMPDAVTHHTCIKS 739
            :|.|  .||    .:|.| ||                  |.|.: |.:..:...|....|....|
Mouse   384 LLYI--GFRGLEGMHCAP-TP------------------DSGVVCGRLACSPTHDEHLMHGTHPS 427

  Fly   740 STEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAPH 804
            ..:.:|..||:|:|:|.::.|..||...|.::|||||.|||||||:.|::|||:.||.:|:|||:
Mouse   428 DGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPN 492

  Fly   805 II 806
            .:
Mouse   493 FV 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	247/498 (50%)
Chrna7	NP_031416.3	LIC	4..490	CDD:273305	254/516 (49%)
		Essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to cell membrane. /evidence=ECO:0000269|PubMed:32783947	260..267		5/6 (83%)