Protein Alignment nAChRalpha5 and Chrna6

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_067344.2
• Gene: Chrna6 / 11440
• MGIID: 106213
• Length: 494
• Species: Mus musculus
• Alignment Length: 531
• Identity: 187/531 - (35%)
• Similarity: 287/531 - (54%)
• Gaps: 51/531 - (9%)

  Fly   272 NSSNSGNSSSTQILNGLNKHSWIFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESD 336
            ||.:.||..|...|       |:...:.|...:..|.:   |::|.|.|...||...|||.|.||
Mouse     3 NSRDQGNLHSGLCL-------WLCGFLALFKGSTGCES---EEQLFHRLFAHYNRFIRPVENVSD 57

  Fly   337 PLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLM 401
            |:.:.|.|.:.|:.:|||.||::.||:||:..|.|..|||:.::|.|::.||:|...|||||:::
Mouse    58 PVTVHFELAITQLANVDEVNQIMETNLWLRHIWKDYRLRWDPTEYDGIETLRVPADNIWKPDIVL 122

  Fly   402 YNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLD 466
            ||:|...|....:|..:::.:|...:.||.||||:|.:|||:||||.|.|.:||||||||..::|
Mouse   123 YNNAVGDFQVEGKTKALLKYDGVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEID 187

  Fly   467 LQLQDETGG--DISSYVLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLII 529
            |.:   .|.  |::.:..|.|||::...|.:::|.||||.|.|.|||::..|||..::|..||||
Mouse   188 LLI---IGSKVDMNDFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLII 249

  Fly   530 PCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMV 594
            ||:.|:.:.:|.|.||.|.|||::|.:::||||||||.::.||:|:||..:||:|.|....|..|
Mouse   250 PCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFV 314

  Fly   595 ASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERK 659
            ..|:|.|:.:||.|:|...||.|.:|::.:||...|.||.|.   :||..........|..|..|
Mouse   315 TLSIVVTVFVLNIHYRTPATHTMPKWVKTIFLQAFPSILMMR---KPLDKTKEAGGVKDPKSHTK 376

  Fly   660 HQILSDVELKERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGS 724
            ..  :.|:...|....||...        |:|:                      ....|.| |.
Mouse   377 RP--AKVKFTHRGESKLLKEC--------HHCQ----------------------KSSDIAP-GK 408

  Fly   725 TRMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTM 789
            .|............|....::..:::.::||.:.::..:|.|::.:|||:.||||||:.|.:|.:
Mouse   409 RRSSQQPARWVAENSEHSSDVEDVIESVQFIAENMKSHNETNEVEDDWKYMAMVVDRVFLWVFII 473

  Fly   790 FTILATIAVLL 800
            ..:..|:.:.|
Mouse   474 VCVFGTVGLFL 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	178/490 (36%)
Chrna6	NP_067344.2	LIC	15..484	CDD:273305	181/517 (35%)
		Neur_chan_LBD	34..240	CDD:280998	92/208 (44%)
		Neur_chan_memb	247..483	CDD:280999	83/271 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..423		4/46 (9%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910