Protein Alignment nAChRalpha5 and CHRND

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_000742.1
• Gene: CHRND / 1144
• HGNCID: 1965
• Length: 517
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 168/558 - (30%)
• Similarity: 270/558 - (48%)
• Gaps: 98/558 - (17%)

  Fly   297 LIYLNLSAKVCLAG----YHEKRLLHDLLDP--YNTLERPVLNESDPLQLSFGLTLMQIIDVDEK 355
            ::.|.|.|.:.:.|    ..|:||:..|...  ||...|||.::.:.:.::..|||..:|.:.|.
Human     5 VLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEV 69

  Fly   356 NQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVR 420
            .:.|.||||::..|.|..|:||..::|.:..||:||..:|.|::::.|:.|..|..:|..||:|.
Human    70 EETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVY 134

  Fly   421 NNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGG---------- 475
            :.|...::||.||:|:|.|.:|:||||.|.|.:||.|..|...::.|.|:.:...
Human   135 HYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWII 199

  Fly   476 -DISSYVLNGEWELLGVPGKRNEIYYNCCPEPYI------DITFAIIIRRRTLYYFFNLIIPCVL 533
             |...:..|||||::..|.:     .|..|...:      ||||.:||||:.|:|..|:::||||
Human   200 IDPEGFTENGEWEIVHRPAR-----VNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVL 259

  Fly   534 IASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSV 598
            |:.|..|.|.||.|||||.|:.:::||:.:|||.::::.:||||.|:||:|.:....|.:|...|
Human   260 ISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVV 324

  Fly   599 VSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGR----PLILEFPTTPCSDTSSERK 659
            |..:::||.|.|...||.:||.::.:||..||.:|.||||..    |..|...::.....|...:
Human   325 VICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGYISKAEE 389

  Fly   660 HQIL---SDVELKERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGP 721
            :.:|   ||:..:::|.:..||             |.:|
Human   390 YFLLKSRSDLMFEKQSERHGLA-------------RRLT-------------------------- 415

  Fly   722 IGSTRMPDAVTHHTCIKSSTEYELGLILKEIR-------FITDQLRKDDECNDIANDWKFAAMVV 779
              :.|.|.|         |:|.....:..|::       ||.:.:|..:..|:..:.|...|..|
Human   416 --TARRPPA---------SSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTV 469

  Fly   780 DRLCLIIFTMFTILATIAVLLSA------PHIIVSXPY 811
            |||||.:.|...::.|..:.|..      |......||
Human   470 DRLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPY 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	161/521 (31%)
CHRND	NP_000742.1	LGIC_ECD_nAChR_D	26..246	CDD:349829	75/224 (33%)
		Cys-loop	151..165	CDD:349829	8/13 (62%)
		Neur_chan_memb	253..489	CDD:460753	81/285 (28%)