Protein Alignment nAChRalpha5 and Chrna4

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_056545.3
• Gene: Chrna4 / 11438
• MGIID: 87888
• Length: 629
• Species: Mus musculus
• Alignment Length: 597
• Identity: 204/597 - (34%)
• Similarity: 295/597 - (49%)
• Gaps: 97/597 - (16%)

  Fly   300 LNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVW 364
            |..|:.:....:.|:|||..|...||...|||.|.||.:.:.|||::.|:||||||||::.||||
Mouse    26 LPASSHIETRAHAEERLLKRLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVW 90

  Fly   365 LKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVP 429
            :|.||:|..|||:..||..|..:|||...||:||:::||:||..|..|:.|...:..:|...:.|
Mouse    91 VKQEWHDYKLRWDPGDYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFYDGRVQWTP 155

  Fly   430 PGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGK 494
            |.|:||:|.||:|:||||.|.|.|||||||||..::|| :...:..|...:..:|||.::...|.
Mouse   156 PAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDL-VSMHSRVDQLDFWESGEWVIVDAVGT 219

  Fly   495 RNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTIL 559
            .|...|.||.|.|.|||:|.||||..|:|..||||||:||:.:.:|.|.||.:.|||::|.:::|
Mouse   220 YNTRKYECCAEIYPDITYAFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKVTLCISVL 284

  Fly   560 LSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIV 624
            |||||||.::.|.:|:||..:||:|.|....|..|..|:|.|:.:||.|||:..||.|..|:|.|
Mouse   285 LSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRV 349

  Fly   625 FLCWLPWILRMSRPG------RPLI---LEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANV 680
            ||..:|.:|.|.||.      |.||   .:....|......|.:..||.|:..:..|......|.
Mouse   350 FLDIVPRLLFMKRPSVVKDNCRRLIESMHKMANAPRFWPEPESEPGILGDICNQGLSPAPTFCNR 414

  Fly   681 LDIDDDFRHNCRP-------------------MTPGGTLP------------------HNPAFYR 708
            :|...:.:..||.                   .:||...|                  |.|:...
Mouse   415 MDTAVETQPTCRSPSHKVPDLKTSEVEKASPCPSPGSCHPPNSSGAPVLIKARSLSVQHVPSSQE 479

  Fly   709 TVYGQ------------GDDGSIG-----PIGS-----------------------TRMPDAVTH 733
            ...|.            ..||:..     |.||                       .:.|..|:.
Mouse   480 AAEGSIRCRSRSIQYCVSQDGAASLTESKPTGSPASLKTRPSQLPVSDQTSPCKCTCKEPSPVSP 544

  Fly   734 HTCIKSS----------TEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFT 788
            .|.:|:.          ....|...::.:::|.|.|:.:|....:..|||:.|||:||:.|.:|.
Mouse   545 ITVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFI 609

  Fly   789 MFTILATIAVLL 800
            :..:|.|:.:.|
Mouse   610 IVCLLGTVGLFL 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	202/584 (35%)
Chrna4	NP_056545.3	LGIC_ECD	39..245	CDD:475126	99/206 (48%)
		Neur_chan_memb	252..620	CDD:460753	99/367 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..459		5/38 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	503..529		3/25 (12%)