Protein Alignment nAChRalpha5 and Chrna1

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_031415.2
• Gene: Chrna1 / 11435
• MGIID: 87885
• Length: 457
• Species: Mus musculus
• Alignment Length: 516
• Identity: 185/516 - (35%)
• Similarity: 290/516 - (56%)
• Gaps: 83/516 - (16%)

  Fly   292 SWIFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKN 356
            |.:.||:.| .||.:.|...||.||:..|.:.|:::.|||.:..:.:|::.||.|:|:|:|||.|
Mouse     4 STVLLLLGL-CSAGLVLGSEHETRLVAKLFEDYSSVVRPVEDHREIVQVTVGLQLIQLINVDEVN 67

  Fly   357 QLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRN 421
            |::.|||.||.:|.|.||:||..||||||.:.||..:||:|||::||:||..|.....|.|::..
Mouse    68 QIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDVVLYNNADGDFAIVKFTKVLLDY 132

  Fly   422 NGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEW 486
            .|...:.||.||||.|:|.:|.||||:|.|.||.|:|||||..:.:..:.:. .|:|:::.:|||
Mouse   133 TGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQ-PDLSNFMESGEW 196

  Fly   487 ELLGVPGKRNEIYYNCCP-EPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGE 550
            .:....|.::.::|:||| .||:|||:..:::|..||:..|:||||:|.:.:..|.|.||.||||
Mouse   197 VIKEARGWKHWVFYSCCPTTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTSLVFYLPTDSGE 261

  Fly   551 KLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTH 615
            |::|.:::||||||||.::.|.:|:||.||||:|.|....|..|.:|::.|::::|.|||:..||
Mouse   262 KMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTH 326

  Fly   616 EMSEWIRIVFLCWLPWIL---RMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLL 677
            .|.||:|.||:..:|.|:   .|.||.|              ..:.|.....|:::.:.|.|
Mouse   327 IMPEWVRKVFIDTIPNIMFFSTMKRPSR--------------DKQEKRIFTEDIDISDISGK--- 374

  Fly   678 ANVLDIDDDFRHNCRPMTPGGTLP-----HNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCI 737
                              ||   |     |:|                          :..|..:
Mouse   375 ------------------PG---PPPMGFHSP--------------------------LIKHPEV 392

  Fly   738 KSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAV 798
            ||:.|        .:::|.:.::.|.|.|:.|.:||:.|||:|.:.|.:|.:..::.|:||
Mouse   393 KSAIE--------GVKYIAETMKSDQESNNAAEEWKYVAMVMDHILLGVFMLVCLIGTLAV 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	177/495 (36%)
Chrna1	NP_031415.2	Neur_chan_LBD	24..231	CDD:308532	90/207 (43%)
		Neur_chan_memb	238..446	CDD:308533	84/280 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910