Protein Alignment nAChRalpha5 and CHRNB4

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_000741.1
• Gene: CHRNB4 / 1143
• HGNCID: 1964
• Length: 498
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 196/516 - (37%)
• Similarity: 289/516 - (56%)
• Gaps: 54/516 - (10%)

  Fly   307 CLAGYHEKRLLHDLLDP--YNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEW 369
            |.....|::|:.|||:.  ||.|.||..:.|..:.:...|:|.|:|.|:|:.|::.||||||.||
Human    21 CRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEW 85

  Fly   370 NDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFK 434
            .|..|.||:|.|.||..||||..|||.||:::||:||..::.:..||::||:|||.|::||.|:|
Human    86 TDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYK 150

  Fly   435 STCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGKRNEIY 499
            |.|||::.:||||.|.|.:||.|||||..::|:.|...| ..:..:..:|||:::.:||:|.
Human   151 SACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPT-ASMDDFTPSGEWDIVALPGRRT--- 211

  Fly   500 YNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTV 564
            .|.....|:|:|:..||:|:.|:|..||||||||...:|:|.|.||.|.|||::|.:::||:||.
Human   212 VNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTF 276

  Fly   565 FLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWL 629
            ||.::::.:|.||..|||:|.|....|.:|..|:|:::.:||.|||:..||.|:.|::..||..|
Human   277 FLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKL 341

  Fly   630 PWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANVLDIDDDFRHNCRP- 693
            |..|.|.|||            .|:|..|...          .|||.:.             :|
Human   342 PTFLFMKRPG------------PDSSPARAFP----------PSKSCVT-------------KPE 371

  Fly   694 MTPGGTLPHNPAFY-RTVY--GQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEY--ELGLILKEIR 753
            .|...|.|.|  || .::|  ......|..|.|||  |.|:.....::||..:  ::...|:.:.
Human   372 ATATSTSPSN--FYGNSMYFVNPASAASKSPAGST--PVAIPRDFWLRSSGRFRQDVQEALEGVS 432

  Fly   754 FITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLS---APHIIVSXPY 811
            ||...::.|||...:..|||:.|||||||.|.:|....:|.|:.:.|.   ..|.... ||
Human   433 FIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPPLFQTHAASEGPY 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	192/499 (38%)
CHRNB4	NP_000741.1	LIC	5..480	CDD:455710	192/501 (38%)
		LGIC_ECD	54..231	CDD:475126	80/180 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..377		6/42 (14%)