Protein Alignment nAChRalpha5 and CHRNB3

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_000740.1
• Gene: CHRNB3 / 1142
• HGNCID: 1963
• Length: 458
• Species: Homo sapiens
• Alignment Length: 530
• Identity: 176/530 - (33%)
• Similarity: 277/530 - (52%)
• Gaps: 105/530 - (19%)

  Fly   293 WIFLLIYLNLSAKVCLAGY-----HEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDV 352
            ::.:||.|.:.:. ...|:     :|..||..|...|....||||:.:|.:::.|||.:.|::||
Human     5 FMLVLIVLGIPSS-ATTGFNSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDV 68

  Fly   353 DEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNV 417
            ||||||:.||||||.||.|..||||..||||:..:::|...:|.||::::.:||..|:|:..|.|
Human    69 DEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKV 133

  Fly   418 VVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVL 482
            :|::||:.::.||..:||:|.:|:|:||||.|.|.||||||||||..:||.|.:| ..|...:..
Human   134 IVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINE-NVDRKDFFD 197

  Fly   483 NGEWELL---GVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTL 544
            |||||:|   |:.|.|.:..|:     |..||::.::||..|:|...|||||:.::.:.:|.|.|
Human   198 NGEWEILNAKGMKGNRRDGVYS-----YPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYL 257

  Fly   545 PPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHH 609
            |.|.||||||..::|:||||||.::.|.:|::|..:||:|.|...||..|..|::.|:.::|.||
Human   258 PSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHH 322

  Fly   610 RNADT-HEMSEWIRIVFLCWLPWIL-------RMSRPGRPLILEFPTTPCSDTSSERKHQILSDV 666
            |::.| |.|:.|::.:||..||.:|       |.|.|                ..|....::...
Human   323 RSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSP----------------EKEESQPVVKGK 371

  Fly   667 ELKERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAV 731
            .|:::..|.|                                      .||
Human   372 VLEKKKQKQL--------------------------------------SDG-------------- 384

  Fly   732 THHTCIKSSTEYELGLILKE----IRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTI 792
                      |..|...|::    ||:|:..::|:...:.:..||||.|.|:||:.|.:|.:.::
Human   385 ----------EKVLVAFLEKAADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSV 439

  Fly   793 LATIAVLLSA 802
            ..::.:...|
Human   440 TGSVLIFTPA 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	171/503 (34%)
CHRNB3	NP_000740.1	Neur_chan_LBD	23..449	CDD:332142	171/509 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910