DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha5 and CHRNB2

DIOPT Version :9

Sequence 1:NP_001356885.1 Gene:nAChRalpha5 / 34826 FlyBaseID:FBgn0028875 Length:837 Species:Drosophila melanogaster
Sequence 2:NP_000739.1 Gene:CHRNB2 / 1141 HGNCID:1962 Length:502 Species:Homo sapiens


Alignment Length:507 Identity:188/507 - (37%)
Similarity:276/507 - (54%) Gaps:75/507 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   313 EKRLLHDLLDP--YNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLR 375
            |:||:..||||  ||.|.||..|.|:.:.:...::|.|:|.|.|:.|::.|||||..||.|..|.
Human    29 EERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLT 93

  Fly   376 WNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKID 440
            |...::..:|.:|:|...||.|||::||:||..::.::.:|.||..:||..::||.|:||.|||:
Human    94 WKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIE 158

  Fly   441 ITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGKRNEIYYNCCPE 505
            :..||||.|.|.|||.|||||..::||.|:.|. ..:..:..:|||:::.:||:|||   |....
Human   159 VKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEV-ASLDDFTPSGEWDIVALPGRRNE---NPDDS 219

  Fly   506 PYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVA 570
            .|:|||:..||||:.|:|..|||||||||.|:|:|.|.||.|.|||::|.:::||:|||||.:::
Human   220 TYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLIS 284

  Fly   571 ETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRM 635
            :.:|.||..|||:|.|....|.:|..|:|:::.:||.|||:..||.|:.|:::|||..||.:|.|
Human   285 KIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFM 349

  Fly   636 SRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANVLDIDDDFRHNCRPMTPGGTL 700
            .:|                   |.|.....:.|:.|.                   |.....|.|
Human   350 QQP-------------------RHHCARQRLRLRRRQ-------------------REREGAGAL 376

  Fly   701 PHNPAFYRTVYGQGD----------DGSIGPIGSTRMPDA---VTHHTCIKSSTEYELGLILKE- 751
                 |:|...|...          .|..|..|:...|.|   .:...|         |..|:| 
Human   377 -----FFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPC---------GCGLREA 427

  Fly   752 ---IRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLL 800
               :|||.|.:|.:|:...::.|||:.|||:|||.|.||....:..||.:.|
Human   428 VDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFL 479

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha5NP_001356885.1 LIC 313..802 CDD:273305 188/507 (37%)
CHRNB2NP_000739.1 LIC 29..479 CDD:273305 187/505 (37%)
LGIC_ECD_nAChR_B2 31..234 CDD:349826 89/206 (43%)
Cys-loop 155..169 CDD:349826 8/13 (62%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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