DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha5 and CHRNB1

DIOPT Version :9

Sequence 1:NP_001356885.1 Gene:nAChRalpha5 / 34826 FlyBaseID:FBgn0028875 Length:837 Species:Drosophila melanogaster
Sequence 2:NP_000738.2 Gene:CHRNB1 / 1140 HGNCID:1961 Length:501 Species:Homo sapiens


Alignment Length:527 Identity:170/527 - (32%)
Similarity:266/527 - (50%) Gaps:81/527 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   313 EKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWN 377
            |.||...|...|::..||.....|.:::|.||.|.|:|.::||::.:.|.|:|.|||.|..|.|:
Human    27 EGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWD 91

  Fly   378 TSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDIT 442
            .:::.|:..|||....:|.|||::.|:.|..||.....:|||.::||..:.||||::|:|.|.:|
Human    92 PAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVT 156

  Fly   443 WFPFDDQRCEMKFGSWTYDGFQLDLQL--------QDETGGDISSYVLNGEWELLGVP------- 492
            :||||.|.|.|.|.|::||..::.||.        ..|......:::.||:||::..|       
Human   157 YFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPP 221

  Fly   493 --------GKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSG 549
                    |:|.|            :.|.:||||:.|:|..|:|.||:||..:|:..|.||||:|
Human   222 GDPRGGREGQRQE------------VIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAG 274

  Fly   550 EKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADT 614
            ||:.|.:..||:|||||.::|:.:|.||.:||::..|....|.:|..||:.::::||.|||:..|
Human   275 EKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHT 339

  Fly   615 HEMSEWIRIVFLCWLPWILRMSR--PGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLL 677
            |:|..|:|.:|:..||..||:.|  |.|.|:.|.|  .||...|..... ..:..:::..|..|.
Human   340 HQMPLWVRQIFIHKLPLYLRLKRPKPERDLMPEPP--HCSSPGSGWGRG-TDEYFIRKPPSDFLF 401

  Fly   678 ANVLDIDDDFRHNCRPMTPGGTLPH--NPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSS 740
            ..                |....|.  .|...|.:.|.....::.|                   
Human   402 PK----------------PNRFQPELSAPDLRRFIDGPNRAVALLP------------------- 431

  Fly   741 TEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAP-H 804
               ||..::..|.:|..||::.::.:.:..||:|.|||||||.|..|.:||.:.|:.:.|.|. |
Human   432 ---ELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIFLDATYH 493

  Fly   805 IIVSXPY 811
            :... |:
Human   494 LPPPDPF 500

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha5NP_001356885.1 LIC 313..802 CDD:273305 167/515 (32%)
CHRNB1NP_000738.2 Neur_chan_LBD 27..245 CDD:308532 77/229 (34%)
Neur_chan_memb 252..487 CDD:308533 86/275 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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