Protein Alignment nAChRalpha5 and CHRNB1

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_000738.2
• Gene: CHRNB1 / 1140
• HGNCID: 1961
• Length: 501
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 170/527 - (32%)
• Similarity: 266/527 - (50%)
• Gaps: 81/527 - (15%)

  Fly   313 EKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWN 377
            |.||...|...|::..||.....|.:::|.||.|.|:|.::||::.:.|.|:|.|||.|..|.|:
Human    27 EGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWD 91

  Fly   378 TSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDIT 442
            .:::.|:..|||....:|.|||::.|:.|..||.....:|||.::||..:.||||::|:|.|.:|
Human    92 PAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVT 156

  Fly   443 WFPFDDQRCEMKFGSWTYDGFQLDLQL--------QDETGGDISSYVLNGEWELLGVP------- 492
            :||||.|.|.|.|.|::||..::.||.        ..|......:::.||:||::..|
Human   157 YFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPP 221

  Fly   493 --------GKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSG 549
                    |:|.|            :.|.:||||:.|:|..|:|.||:||..:|:..|.||||:|
Human   222 GDPRGGREGQRQE------------VIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAG 274

  Fly   550 EKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADT 614
            ||:.|.:..||:|||||.::|:.:|.||.:||::..|....|.:|..||:.::::||.|||:..|
Human   275 EKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHT 339

  Fly   615 HEMSEWIRIVFLCWLPWILRMSR--PGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLL 677
            |:|..|:|.:|:..||..||:.|  |.|.|:.|.|  .||...|..... ..:..:::..|..|.
Human   340 HQMPLWVRQIFIHKLPLYLRLKRPKPERDLMPEPP--HCSSPGSGWGRG-TDEYFIRKPPSDFLF 401

  Fly   678 ANVLDIDDDFRHNCRPMTPGGTLPH--NPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSS 740
            ..                |....|.  .|...|.:.|.....::.|
Human   402 PK----------------PNRFQPELSAPDLRRFIDGPNRAVALLP------------------- 431

  Fly   741 TEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAP-H 804
               ||..::..|.:|..||::.::.:.:..||:|.|||||||.|..|.:||.:.|:.:.|.|. |
Human   432 ---ELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIFLDATYH 493

  Fly   805 IIVSXPY 811
            :....|:
Human   494 LPPPDPF 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	167/515 (32%)
CHRNB1	NP_000738.2	LGIC_ECD_nAChR_B1	27..245	CDD:349825	77/229 (34%)
		Cys-loop	151..165	CDD:349825	8/13 (62%)
		Neur_chan_memb	252..487	CDD:460753	86/275 (31%)