DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha5 and CHRNA7

DIOPT Version :9

Sequence 1:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001177384.1	Gene:	CHRNA7 / 1139	HGNCID:	1960	Length:	531	Species:	Homo sapiens

Alignment Length:	514	Identity:	250/514 - (48%)
Similarity:	337/514 - (65%)	Gaps:	51/514 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 VCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWN 370
            |.|.|..:::|..:|:..||.|||||.|:|.||.:.|.|:|:||:|||||||:|.||:||::.|.
Human    48 VSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWT 112

  Fly   371 DMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKS 435
            |..|:||.|:|.|||.:|.|..:|||||:|:||||||.||.|:.|||:|.::|.|.|:|||||||
Human   113 DHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKS 177

  Fly   436 TCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGKRNEIYY 500
            :|.||:.|||||.|.|::|||||:|.|:.||||:|:   .|||.|:.||||:|:|:||||:|.:|
Human   178 SCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQE---ADISGYIPNGEWDLVGIPGKRSERFY 239

  Fly   501 NCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVF 565
            .||.|||.|:||.:.:|||||||..||:||||||:::|||.|.||.|||||:|||:|:|||||||
Human   240 ECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVF 304

  Fly   566 LNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLP 630
            :.:|||.||||||:|||:..||...|.:|..|||.|:::|.|||.:.|..:|.:|.|::.|.|..
Human   305 MLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCA 369

  Fly   631 WILRMSRPG----RPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANVLDIDDDFRH-- 689
            |.|||.|||    || ..:.....||..|.|     :|.|.....|:    .|:|.|  .||.
Human   370 WFLRMKRPGEDKVRP-ACQHKQRRCSLASVE-----MSAVAPPPASN----GNLLYI--GFRGLD 422

  Fly   690 --NCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTH-----HTCIKSSTEYELGL 747
              :|.| ||                  |.|.:    ..||..:.||     |.......:.:|..
Human   423 GVHCVP-TP------------------DSGVV----CGRMACSPTHDEHLLHGGQPPEGDPDLAK 464

  Fly   748 ILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAPHII 806
            ||:|:|:|.::.|..||...:.::|||||.|||||||:.|::|||:.||.:|:|||:.:
Human   465 ILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFV 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	244/501 (49%)
CHRNA7	NP_001177384.1	LIC	3..519	CDD:273305	247/508 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	282	1.000	Domainoid score	I1660
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H593
Inparanoid	1	1.050	482	1.000	Inparanoid score	I1468
Isobase	1	0.950	-	0	Normalized mean entropy	S3299
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	1	1.000	-	-		mtm8451
orthoMCL	1	0.900	-	-		OOG6_104534
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3025
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.810