Protein Alignment nAChRalpha5 and CHRNA5

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_000736.2
• Gene: CHRNA5 / 1138
• HGNCID: 1959
• Length: 468
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 181/523 - (34%)
• Similarity: 272/523 - (52%)
• Gaps: 105/523 - (20%)

  Fly   296 LLIYLNLSAKVC-LAG----------------YHEKRLLHDLLDPYNTLERPVLNESDPLQLSFG 343
            ||:.:.|.|..| |||                .||..||.||...|....|||.:.:|.:::.||
Human    13 LLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFG 77

  Fly   344 LTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEG 408
            |.:.|::||||||||:.||||||.||.|:.||||..||||:|.:|:|...:|.||::::::||..
Human    78 LAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGR 142

  Fly   409 FDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDET 473
            |:|| .|..|:|.||:..:.||..:||:|.||:|:||||.|.|.||||||||||.|:|:.|:|:
Human   143 FEGT-STKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQ- 205

  Fly   474 GGDISSYVLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMA 538
            ..|...:..|||||::...|.:.....:||..||  :|::.:|:|..|:|...|||||:.::.:.
Human   206 DVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPY--VTYSFVIKRLPLFYTLFLIIPCIGLSFLT 268

  Fly   539 LLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTIL 603
            :|.|.||.:.|||:.|..::|:||||||.::.|.:|::|..:||:|.|....|..|..|::.|:.
Human   269 VLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVF 333

  Fly   604 ILNYHHRNADTHE-MSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVE 667
            .:|.|||::.||. |:..:|.:||..||.:|.|                      |.|
Human   334 AINIHHRSSSTHNAMAPLVRKIFLHTLPKLLCM----------------------RSH------- 369

  Fly   668 LKERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVT 732
                           :|.                     |.|...:.:.|| ||
Human   370 ---------------VDR---------------------YFTQKEETESGS-GP----------- 386

  Fly   733 HHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIA 797
                  .|:...|...|..||:||..:.|:::..::..||||.|.|:||:.|..|...:|:.::.
Human   387 ------KSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLG 445

  Fly   798 VLL 800
            :.:
Human   446 LFV 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	172/489 (35%)
CHRNA5	NP_000736.2	LIC	39..449	CDD:273305	173/497 (35%)
		Neur_chan_LBD	47..250	CDD:280998	97/206 (47%)
		Neur_chan_memb	257..447	CDD:280999	73/272 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910