Protein Alignment nAChRalpha5 and CHRNA4

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_000735.1
• Gene: CHRNA4 / 1137
• HGNCID: 1958
• Length: 627
• Species: Homo sapiens
• Alignment Length: 616
• Identity: 204/616 - (33%)
• Similarity: 300/616 - (48%)
• Gaps: 135/616 - (21%)

  Fly   300 LNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVW 364
            |..|:.|....:.|:|||..|...||...|||.|.||.:.:.|||::.|:||||||||::.||||
Human    24 LRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVW 88

  Fly   365 LKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVP 429
            :|.||:|..|||:.:||..|..:|||...||:||:::||:||..|..|:.|...:.::|...:.|
Human    89 VKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTP 153

  Fly   430 PGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGK 494
            |.|:||:|.||:|:||||.|.|.|||||||||..::|| :...:..|...:..:|||.::...|.
Human   154 PAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDL-VNMHSRVDQLDFWESGEWVIVDAVGT 217

  Fly   495 RNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTIL 559
            .|...|.||.|.|.|||:|.:|||..|:|..||||||:||:.:.:|.|.||.:.|||::|.:::|
Human   218 YNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVL 282

  Fly   560 LSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIV 624
            |||||||.::.|.:|:||..:||:|.|....|..|..|:|.|:.:||.|||:..||.|..|:|.|
Human   283 LSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRV 347

  Fly   625 FLCWLPWILRMSRP----------------------------GRP-----------------LIL 644
            ||..:|.:|.|.||                            |.|                 :.|
Human   348 FLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPL 412

  Fly   645 EFPTTP---CSDTSSERKHQILSDVELKERSSKSLLANVLDIDDDFRH----NCRPMTPGGT--- 699
            :.|..|   |...|.:...|  ..:|.::.|.               |    .|||  |.||
Human   413 DVPAEPGPSCKSPSDQLPPQ--QPLEAEKASP---------------HPSPGPCRP--PHGTQAP 458

  Fly   700 ---------LPHNPAFYRTVYG--------------------QGDDGSIGPIGS----------- 724
                     :.|..:....|.|                    :.|..:.|.:.|
Human   459 GLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNTHSAELPPP 523

  Fly   725 ----------TRMPDAVTHHTCIKS-STEY---------ELGLILKEIRFITDQLRKDDECNDIA 769
                      .:.|.:|:....:|: ||:.         .|...::.:::|.|.|:.:|....:.
Human   524 DQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVK 588

  Fly   770 NDWKFAAMVVDRLCLIIFTMFTILATIAVLL 800
            .|||:.|||:||:.|.:|.:..:|.|:.:.|
Human   589 EDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	201/603 (33%)
CHRNA4	NP_000735.1	LGIC_ECD	37..243	CDD:475126	98/206 (48%)
		Neur_chan_memb	250..618	CDD:460753	99/386 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	382..481		19/117 (16%)
		PRK14959	<392..496	CDD:184923	19/122 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..561		8/64 (13%)