Protein Alignment nAChRalpha5 and CHRNA3

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_000734.2
• Gene: CHRNA3 / 1136
• HGNCID: 1957
• Length: 505
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 195/512 - (38%)
• Similarity: 297/512 - (58%)
• Gaps: 37/512 - (7%)

  Fly   294 IFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQL 358
            :.||:.|:| ..|..|...|.||...|.:.||.:.|||.|.|||:.:.|.:::.|::.|||.||:
Human    17 LLLLLLLSL-LPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQI 80

  Fly   359 LVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNG 423
            :.||:|||..|||..|:||.|||||.:.:|:|..:|||||:::||:|...|....:|..:::..|
Human    81 METNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTG 145

  Fly   424 SCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWEL 488
            ...::||.||||:||||:|:||||.|.|.||||||:||..::||.|.. :..::..|..:|||.:
Human   146 EVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIG-SSMNLKDYWESGEWAI 209

  Fly   489 LGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLS 553
            :..||.:::|.||||.|.|.|||:::.|||..|:|..||||||:||:.:.:|.|.||.|.|||::
Human   210 IKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVT 274

  Fly   554 LGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMS 618
            |.:::||||||||.::.||:|:||..:||:|.|....|..|..|:|.|:.:||.|:|...||.|.
Human   275 LCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMP 339

  Fly   619 EWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANVLDI 683
            .|::.|||..||.::            |.|.|.|:..:.:|.:.|...||...:..|...:
Human   340 SWVKTVFLNLLPRVM------------FMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAES---- 388

  Fly   684 DDDFRHNCR---PMTPG--GTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEY 743
                 ..|:   |...|  |...|     |.:.......::....|:...|||..    .|:...
Human   389 -----KGCKEGYPCQDGMCGYCHH-----RRIKISNFSANLTRSSSSESVDAVLS----LSALSP 439

  Fly   744 ELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLL 800
            |:...::.:::|.:.::..:|..:|.:|||:.|||:||:.|.:||:..||.|..:.|
Human   440 EIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFL 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	189/493 (38%)
CHRNA3	NP_000734.2	Neur_chan_LBD	30..496	CDD:332142	189/496 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910