Protein Alignment nAChRalpha5 and CHRNA2

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_000733.2
• Gene: CHRNA2 / 1135
• HGNCID: 1956
• Length: 529
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 199/500 - (39%)
• Similarity: 292/500 - (58%)
• Gaps: 40/500 - (8%)

  Fly   310 GYH---EKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWND 371
            |.|   |.||...|...||...|||.|.||.:.:.|||::.|:||||||||::.||||||.||:|
Human    53 GSHTETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSD 117

  Fly   372 MNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKST 436
            ..||||.:|:|.:..||:|...||.||:::||:||..|..|:.|...:.:.|:..:|||.|:||:
Human   118 YKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSS 182

  Fly   437 CKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGKRNEIYYN 501
            |.||:|:||||.|.|:|||||||||..::||:..::| .|:..|..:|||.::...|..|...|:
Human   183 CSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQT-VDLKDYWESGEWAIVNATGTYNSKKYD 246

  Fly   502 CCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFL 566
            ||.|.|.|:|:|.:|||..|:|..||||||:||:.:.:|.|.||.|.|||::|.:::||||||||
Human   247 CCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFL 311

  Fly   567 NMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLP- 630
            .::.|.:|:||..:||:|.|....|..|..|:|.|:.:||.|||:..||.|..|:|...|..:|
Human   312 LLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPR 376

  Fly   631 WILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANVLDIDDDFRHNCR-PM 694
            |:| |:||..|:.|   ..|.....|...|.:.|:|:.:||.        :.::::.|..|. .:
Human   377 WLL-MNRPPPPVEL---CHPLRLKLSPSYHWLESNVDAEERE--------VVVEEEDRWACAGHV 429

  Fly   695 TPG-GTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDA---VTHHTCIKSSTEYELGLILKEIRFI 755
            .|. |||        ..:|....|:.||.....:.:.   ::.|          :...|:.:.:|
Human   430 APSVGTL--------CSHGHLHSGASGPKAEALLQEGELLLSPH----------MQKALEGVHYI 476

  Fly   756 TDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLL 800
            .|.||.:|..:.:..|||:.|||:||:.|.:|.:...|.||.:.|
Human   477 ADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFL 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	196/493 (40%)
CHRNA2	NP_000733.2	LIC	57..522	CDD:273305	196/495 (40%)
		Neur_chan_LBD	59..265	CDD:280998	100/206 (49%)
		Neur_chan_memb	272..520	CDD:280999	93/277 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910