Protein Alignment nAChRalpha5 and CHRNA1

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: XP_016858745.1
• Gene: CHRNA1 / 1134
• HGNCID: 1955
• Length: 489
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 184/543 - (33%)
• Similarity: 288/543 - (53%)
• Gaps: 99/543 - (18%)

  Fly   285 LNGLNKHSWIFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQI 349
            |.|..|:  :.:|:...:||.:.|...||.||:..|...|:::.|||.:....::::.||.|:|:
Human     5 LEGGEKN--LTVLVSSAVSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL 67

  Fly   350 IDVDEKNQLLVTNVWLKL-------------------------EWNDMNLRWNTSDYGGVKDLRI 389
            |:|||.||::.|||.||.                         :|.|.||:||..||||||.:.|
Human    68 INVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHI 132

  Fly   390 PPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMK 454
            |..:||:||:::||:||..|.....|.|:::..|...:.||.||||.|:|.:|.||||:|.|.||
Human   133 PSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMK 197

  Fly   455 FGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGKRNEIYYNCCPE-PYIDITFAIIIRR 518
            .|:|||||..:.:..:.:. .|:|:::.:|||.:....|.::.:.|:|||: ||:|||:..:::|
Human   198 LGTWTYDGSVVAINPESDQ-PDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQR 261

  Fly   519 RTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLL 583
            ..||:..|:||||:|.:.:..|.|.||.|||||::|.:::||||||||.::.|.:|:||.||||:
Human   262 LPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLI 326

  Fly   584 GTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWIL---RMSRPGRPLILE 645
            |.|....|..|.:|::.|::::|.|||:..||.|..|:|.||:..:|.|:   .|.||.|
Human   327 GKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSR----- 386

  Fly   646 FPTTPCSDTSSERKHQILSDVELKERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTV 710
                                    |:..|.:....:||.|
Human   387 ------------------------EKQDKKIFTEDIDISD------------------------- 402

  Fly   711 YGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFA 775
                ..|..||      |....|...||..   |:...::.|::|.:.::.|.|.|:.|.:||:.
Human   403 ----ISGKPGP------PPMGFHSPLIKHP---EVKSAIEGIKYIAETMKSDQESNNAAAEWKYV 454

  Fly   776 AMVVDRLCLIIFTMFTILATIAV 798
            |||:|.:.|.:|.:..|:.|:||
Human   455 AMVMDHILLGVFMLVCIIGTLAV 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	176/515 (34%)
CHRNA1	XP_016858745.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910