Protein Alignment nAChRalpha5 and Chrna5

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001360830.1
• Gene: Chrna5 / 110835
• MGIID: 87889
• Length: 467
• Species: Mus musculus
• Alignment Length: 509
• Identity: 180/509 - (35%)
• Similarity: 267/509 - (52%)
• Gaps: 93/509 - (18%)

  Fly   309 AGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMN 373
            |..||..|..||.:.|....|||.:.||.:::.|||.:.|::||||||||:.||||||.||.|:.
Mouse    43 AAKHEDSLFRDLFEDYEKWVRPVEHLSDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVK 107

  Fly   374 LRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCK 438
            ||||..||||:|.:|:|...:|.||::::::||..|:|. .|..|||.||:..:..|..:||:|.
Mouse   108 LRWNPDDYGGIKIIRVPSDSLWIPDIVLFDNADGRFEGA-STKTVVRYNGTVTWTQPANYKSSCT 171

  Fly   439 IDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGKRNEIYYNCC 503
            ||:|:||||.|.|.||||||||||.|:|:.|:|: ..|.:.:..|||||::...|.:.....:||
Mouse   172 IDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQ-DVDRTDFFDNGEWEIMSAMGSKGNRTDSCC 235

  Fly   504 PEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNM 568
            ..|.  ||::.:|:|..|:|...|||||:.::.:.::.|.||.:.|||:||..::|:||||||.:
Mouse   236 WYPC--ITYSFVIKRLPLFYTLFLIIPCIGLSFLTVVVFYLPSNEGEKISLCTSVLVSLTVFLLV 298

  Fly   569 VAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHE-MSEWIRIVFLCWLPWI 632
            :.|.:|::|..:||:|.|....|..|..|::.|:..:|.|||::.||. |:.|:|.:||..||.:
Mouse   299 IEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPWVRKIFLHKLPKL 363

  Fly   633 LRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANVLDIDDDFRHNCRPMTPG 697
            |.|                      |.|   :|....:|....
Mouse   364 LCM----------------------RSH---ADRYFTQREEAE---------------------- 381

  Fly   698 GTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKD 762
                             .||  ||                ||....|..|..  ||:||..:.|:
Mouse   382 -----------------KDG--GP----------------KSRNTLEAALDC--IRYITRHVVKE 409

  Fly   763 DECNDIANDWKFAAMVVDRLCLIIFTMFTILAT----IAVLLSAPHIIVSXPYG 812
            ::..::..||||.|.|:||:.|..|.:.:|:.|    :.|:....:|||....|
Mouse   410 NDVREVVEDWKFIAQVLDRMFLWTFLLVSIIGTLGLFVPVIYKWANIIVPVHIG 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	174/493 (35%)
Chrna5	NP_001360830.1	LGIC_ECD	45..251	CDD:355788	97/209 (46%)
		Neur_chan_memb	257..445	CDD:367256	75/271 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910