DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha5 and Chrna3

DIOPT Version :9

Sequence 1:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_660111.3	Gene:	Chrna3 / 110834	MGIID:	87887	Length:	499	Species:	Mus musculus

Alignment Length:	510	Identity:	193/510 - (37%)
Similarity:	295/510 - (57%)	Gaps:	36/510 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 LLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLV 360
            :|:.:.:...|..|...|.||...|.:.||.:.|||.|.|.|:.:.|.:::.|::.|||.||::.
Mouse    12 MLMLVLMLLPVASASEAEHRLFQYLFEDYNEIIRPVANVSHPVIIQFEVSMSQLVKVDEVNQIME 76

  Fly   361 TNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSC 425
            ||:|||..|||..|:|..|||.||:.:|:|..:|||||:::||:||..|....:|..:::..|..
Mouse    77 TNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNNADGDFQVDDKTKALLKYTGEV 141

  Fly   426 LYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLG 490
            .::||.||||:||||:|:||||.|.|.||||||:||..::||.|.. :..::..|..:|||.::.
Mouse   142 TWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIG-SSMNLKDYWESGEWAIIK 205

  Fly   491 VPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLG 555
            .||.::||.||||.|.|.|||:::.|||..|:|..||||||:||:.:.:|.|.||.|.|||::|.
Mouse   206 APGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLC 270

  Fly   556 VTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEW 620
            :::||||||||.::.||:|:||..:||:|.|....|..|..|:|.|:.:||.|:|...||.|..|
Mouse   271 ISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPTW 335

  Fly   621 IRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKH--QILSDVELKERS-SKSLLANVLD 682
            ::.|||..||.::.|:|         ||:...|....|..  ..||::....|: |||
Mouse   336 VKAVFLNLLPRVMFMTR---------PTSTEEDAPKTRNFYGAELSNLNCFSRADSKS------- 384

  Fly   683 IDDDFRHNCRPMTP--GGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYEL 745
                    |:...|  .||..:  ..:|.|.......::....|:...|||..    .|:...|:
Mouse   385 --------CKEGYPCQDGTCGY--CHHRRVKISNFSANLTRSSSSESVDAVLS----LSALSPEI 435

  Fly   746 GLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLL 800
            ...::.:::|.:.::..:...:|.:|||:.|||:||:.|.:|.:..||.|..:.|
Mouse   436 KEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFL 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	190/493 (39%)
Chrna3	NP_660111.3	LIC	24..490	CDD:273305	190/496 (38%)
		LGIC_ECD_nAChR_A3	29..235	CDD:349817	96/206 (47%)
		Cys-loop	153..167	CDD:349817	10/13 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910