Protein Alignment nAChRalpha5 and Chrnb3

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_775304.1
• Gene: Chrnb3 / 108043
• MGIID: 106212
• Length: 464
• Species: Mus musculus
• Alignment Length: 536
• Identity: 184/536 - (34%)
• Similarity: 277/536 - (51%)
• Gaps: 123/536 - (22%)

  Fly   292 SWIFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKN 356
            ||:.|.....||:    ...||..||..|...|....|||||.||.:::.|||.:.|::||||||
Mouse    18 SWVTLTATAGLSS----VAEHEDALLRHLFQGYQKCVRPVLNSSDIIKVYFGLKISQLVDVDEKN 78

  Fly   357 QLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRN 421
            ||:.||||||.||.|..||||..||||:..:::|...:|.||::::.:||..|:|:..|..:|::
Mouse    79 QLMTTNVWLKQEWTDQKLRWNPEDYGGINSIKVPSESLWLPDIVLFENADGRFEGSLMTKAIVKS 143

  Fly   422 NGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEW 486
            :|:..:.||..:||:|.:|:|:||||.|.|.||||||||||..:||.|.:| ..|...:..||||
Mouse   144 SGTVSWTPPASYKSSCTMDVTFFPFDKQNCSMKFGSWTYDGTMVDLILINE-NVDRKDFFDNGEW 207

  Fly   487 ELL---GVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDS 548
            |:|   |:.|.|.|.:|:     |..:|::.::||..|:|...|||||:.::.:.:|.|.||.|.
Mouse   208 EILNAKGMKGNRREGFYS-----YPFVTYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDE 267

  Fly   549 GEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNAD 613
            ||||||..::|:||||||.::.|.:|::|..:||:|.|...||..|..|::.|:.::|.|||::.
Mouse   268 GEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSS 332

  Fly   614 T-HEMSEWIRIVFLCWLP-WIL------RMSRP----------GRPLILEFP----TTPCSDTSS 656
            | |.|:.|::.:||..|| |:.      |.|.|          |:     ||    .||.||  .
Mouse   333 TYHPMAPWVKRLFLEKLPRWLCMKDPRDRFSFPDGTESKGTVRGK-----FPGKKKQTPTSD--G 390

  Fly   657 ERKHQILSDVELKERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGP 721
            ||   :|  |...|::|:|
Mouse   391 ER---VL--VAFLEKASES---------------------------------------------- 404

  Fly   722 IGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLII 786
                                          ||:|:..::|:...:.:..||||.|.|:||:.|.:
Mouse   405 ------------------------------IRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWL 439

  Fly   787 FTMFTILATIAVLLSA 802
            |...::|.::.:.:.|
Mouse   440 FLTASVLGSVLIFIPA 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	177/513 (35%)
Chrnb3	NP_775304.1	LIC	6..455	CDD:273305	183/534 (34%)
		Neur_chan_LBD	35..239	CDD:280998	95/209 (45%)
		Neur_chan_memb	246..452	CDD:280999	80/293 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	368..387		4/23 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910