Protein Alignment nAChRalpha5 and Chrnb4

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_683746.1
• Gene: Chrnb4 / 108015
• MGIID: 87892
• Length: 495
• Species: Mus musculus
• Alignment Length: 519
• Identity: 195/519 - (37%)
• Similarity: 295/519 - (56%)
• Gaps: 57/519 - (10%)

  Fly   297 LIYLNLSAKV----CLAGYHEKRLLHDLLDP--YNTLERPVLNESDPLQLSFGLTLMQIIDVDEK 355
            |:.::|.|.:    |.....|::|:.|||:.  ||.|.||..:.|..:.:...|:|.|:|.|:|:
Mouse     6 LLLVSLFALLQPGDCRLANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIRLELSLSQLISVNER 70

  Fly   356 NQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVR 420
            .|::.|::|||.||.|..|.||:|.|.||..||||..|:|.||:::||:||..::.:..|||:||
Mouse    71 EQIMTTSIWLKQEWTDYRLAWNSSCYEGVNILRIPAKRVWLPDIVLYNNADGTYEVSVYTNVIVR 135

  Fly   421 NNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGE 485
            :|||..::||.|:||.|||::..||||.|.|.:||.|||||..::|:.|:..| ..:..:..:||
Mouse   136 SNGSIQWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLKSPT-AIMDDFTPSGE 199

  Fly   486 WELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGE 550
            |:::.:||:|.   .|.....|:|:|:..||:|:.|:|..|||||||||.|:|:|.|.||.|.||
Mouse   200 WDIVALPGRRT---VNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGE 261

  Fly   551 KLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTH 615
            |::|.:::||:||.||.::::.:|.||..:||:|.|....|.:|..|:|:|:.:||.|||:..||
Mouse   262 KMTLCISVLLALTFFLLLISKIVPPTSLDIPLIGKYLLFTMVLVTFSIVTTVCVLNVHHRSPSTH 326

  Fly   616 EMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANV 680
            .|:.|::..||..||..|.|.|||    ||  .:|.....|.:.|     :...|.:|.|.|.
Mouse   327 TMASWVKECFLHKLPTFLFMKRPG----LE--VSPARVPHSSQLH-----LTTAEATSTSALG-- 378

  Fly   681 LDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTC-------IK 738
                        |.:|.....::..|            :.|:.:| ...||:.||.       ::
Mouse   379 ------------PSSPSNLYGNSMYF------------VNPVPAT-PKSAVSSHTAGLPRDARLR 418

  Fly   739 SSTEY--ELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLL 800
            ||..:  :|...|:.:.||...|..||....:..||||.|||||||.|.:|.:..||.|:.:.|
Mouse   419 SSGRFRQDLQEALEGVSFIAQHLESDDRDQSVIEDWKFVAMVVDRLFLWVFVIVCILGTMGLFL 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	191/499 (38%)
Chrnb4	NP_683746.1	LIC	21..483	CDD:455710	191/504 (38%)
		LGIC_ECD	53..230	CDD:475126	77/180 (43%)