DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha5 and LOC101882451

DIOPT Version :9

Sequence 1:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_005174278.4	Gene:	LOC101882451 / 101882451	-ID:	-	Length:	545	Species:	Danio rerio

Alignment Length:	570	Identity:	257/570 - (45%)
Similarity:	342/570 - (60%)	Gaps:	78/570 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   266 SSSSSSNSSNSGNSSSTQILNGLNKHSWIFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERP 330
            |..||.:|.:.|...|.....|      ...|:...|...|.|.|.|::||..||:..||.||||
Zfish    16 SCVSSGDSCSLGAGVSVMGSGG------TLALLSAALLLHVSLQGEHQRRLYRDLMKNYNPLERP 74

  Fly   331 VLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIW 395
            |.|:|..|.:.|..:||||:|||||||:|.||:||:|.|.|..||||.|||.||..:|.|...||
Zfish    75 VYNDSHSLTVHFSFSLMQIMDVDEKNQVLTTNIWLQLYWTDYYLRWNMSDYPGVNTVRFPDSLIW 139

  Fly   396 KPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTY 460
            :||:|:||||||.||.|:.|||:|.::|.|.|:|||||||||.||:.|||||.|||::|||||||
Zfish   140 RPDILLYNSADERFDATFHTNVLVNSSGYCQYLPPGIFKSTCYIDVRWFPFDVQRCDLKFGSWTY 204

  Fly   461 DGFQLDLQLQDETGGDISSYVLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFF 525
            .|:.||||:   ...||:.|:.||||:|:.|||:|||.:|:||.|||.|:||.:::|||||||..
Zfish   205 GGWALDLQM---INADITGYIANGEWDLVEVPGRRNEKFYDCCKEPYPDVTFTVVMRRRTLYYGL 266

  Fly   526 NLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCI 590
            ||:||||||:::|||.|.||.|||||:|||:|:|||||||:.:|||.||||||:|||:..||...
Zfish   267 NLLIPCVLISTLALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFATT 331

  Fly   591 MFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTS 655
            |.:|..||::|:|:|.||:.:.|..:|.:|.|::.|.|..|.|||.|||...|    ...|.:..
Zfish   332 MVIVGLSVIATVLVLQYHYHDPDGAKMPKWTRVLLLNWCAWFLRMRRPGEDRI----RLACHNKP 392

  Fly   656 SERKHQILSDVELK---------------------------ERSSKSLLANVL--DIDDDFRHNC 691
            :.|..  :|.|||.                           ...|.|:|.:.|  :.:||.
Zfish   393 ARRSS--VSSVELSVSQGALQAAGGNMLYFGFRGMEGVHYTAHESHSVLCSRLMANSEDDV---- 451

  Fly   692 RPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFIT 756
              :.||.          .:.|....|.:|                  .:.|.||..||:|:|:|.
Zfish   452 --LLPGA----------QIRGGVTSGIVG------------------GTLELELAKILEEVRYIA 486

  Fly   757 DQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAPHII 806
            .:.|..|....:.|:|||||.|:|||||:.|::||||.||.:|:|||:.:
Zfish   487 KRFRDQDADESVCNEWKFAAAVIDRLCLMAFSIFTILCTIGILMSAPNFV 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	241/517 (47%)
LOC101882451	XP_005174278.4	Neur_chan_LBD	55..532	CDD:332142	242/519 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	288	1.000	Domainoid score	I1532
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	510	1.000	Inparanoid score	I1280
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	1	1.000	-	-		mtm6506
orthoMCL	1	0.900	-	-		OOG6_104534
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.970