Protein Alignment nAChRalpha5 and chrne

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: XP_002941867.4
• Gene: chrne / 100497712
• XenbaseID: XB-GENE-979686
• Length: 505
• Species: Xenopus tropicalis
• Alignment Length: 540
• Identity: 169/540 - (31%)
• Similarity: 268/540 - (49%)
• Gaps: 86/540 - (15%)

  Fly   293 WIFLLIYLNLSAKVCLAG-YHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKN 356
            ::.|||.|:.|    ||. ..|.||:..|...|::..||.....|.:.:|..|||..:||::||.
 Frog     7 FLSLLILLHNS----LANESEESRLIKYLFTNYDSKARPSKGIDDVVPVSLKLTLTNLIDLNEKE 67

  Fly   357 QLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRN 421
            :.|.||||:::.|.|..|.||.::|||:..:::|...:|.|::::.|:.|..|:..|..||:|.:
 Frog    68 ETLTTNVWVQIAWQDDRLTWNETEYGGMPLVQVPHDMMWLPEIVLENNIDGNFEVAYYANVLVHS 132

  Fly   422 NGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQL--QDETG-------GDI 477
            .|...::||.||:|||.|:||:||||.|.|.:.|.|.||....:||.|  .||||       .|.
 Frog   133 TGYIYWLPPAIFRSTCSIEITYFPFDWQNCSLVFRSKTYSANDIDLHLVADDETGLPFDQVDIDR 197

  Fly   478 SSYVLNGEWELLGVPGKR--NEIYYNCCPEP--YIDITFAIIIRRRTLYYFFNLIIPCVLIASMA 538
            .::..||||.::..|.::  |..|   ..|.  |.:|.|.:||:|:.|:|..|:|:|||||:|:.
 Frog   198 EAFTENGEWAIMHRPARKIVNPKY---SKEDLRYQEIVFILIIQRKPLFYIINIIVPCVLISSLV 259

  Fly   539 LLGFTLPPDS-GEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTI 602
            :|.:.||..: |:|.::.:::||:.||||.::|:.:|.||.:|||:|.|...:||:....|:|.:
 Frog   260 VLVYFLPAKAGGQKCTVSISVLLAQTVFLFLIAQMIPETSLSVPLIGKYLMFVMFVSTLIVLSCV 324

  Fly   603 LILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPC---SDTSSERKHQIL- 663
            ::||...|:..||.:|..::.:.|..||..:.:.           ..||   .:|..||:...|
 Frog   325 IVLNVSLRSPSTHTLSSKVKHMLLEVLPQFIHLR-----------VEPCDEGEETPRERRRSSLG 378

  Fly   664 -----SDVELKERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIG 723
                 .:..||:..|:.:.....:     ||..|         ..|..||.      ||.  .:|
 Frog   379 IMLKAEEYVLKKPRSELMFERQRE-----RHGMR---------REPDGYRA------DGF--DVG 421

  Fly   724 STRMPDAVTHHTCIKSSTEY-ELGLILKEIR-------FITDQLRKDDECNDIANDWKFAAMVVD 780
            .|              :|.| .|.....||:       |||...:.|:.......:|.....|:|
 Frog   422 VT--------------TTLYRNLAQCAPEIKDCVDACNFITQNTKDDNATGAEMENWVLIGKVLD 472

  Fly   781 RLCLIIFTMFTILATIAVLL 800
            .||..:.....:|.|:|:.|
 Frog   473 VLCFWVALPLFVLGTLAIFL 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	162/519 (31%)
chrne	XP_002941867.4	LGIC_ECD_nAChR_G	47..241	CDD:349830	75/196 (38%)
		Cys-loop	148..162	CDD:349830	9/13 (69%)
		Neur_chan_memb	248..491	CDD:460753	76/289 (26%)