DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha5 and chrna10

DIOPT Version :9

Sequence 1:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_031753261.1	Gene:	chrna10 / 100487976	-ID:	-	Length:	501	Species:	Xenopus tropicalis

Alignment Length:	516	Identity:	184/516 - (35%)
Similarity:	289/516 - (56%)	Gaps:	43/516 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 LSAKVCL-------AGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLL 359
            |:..:||       .|....:|::||...|:...|||.:....:.::..:||.||||:||:||:|
Frog     7 LACCLCLLPGVQGAQGRFAYKLMNDLFANYSNALRPVEDMDKAMNVTLQVTLSQIIDMDERNQIL 71

  Fly   360 VTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGS 424
            :..:|::..|.|..||||..||.|:..:|||...:|:||:::||:||:.|.|:.:||||:|.:|.
Frog    72 MAYLWIRQVWFDAYLRWNKEDYDGLDTIRIPSSYVWRPDIVLYNNADDQFTGSMETNVVIRYDGQ 136

  Fly   425 CLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELL 489
            .::..|.|.||:||:|:::||||.|:|.:.||||||:|.|:|:....:| ||::.:|.|.|||:|
Frog   137 IMWDSPAITKSSCKVDVSFFPFDGQQCRLTFGSWTYNGNQIDILNHLDT-GDLTDFVENVEWEIL 200

  Fly   490 GVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSL 554
            |:|.|::.|.|.||.|||.|:|:.:|::||..:|.|||::|||:|:.:|.|||.||.|||||:||
Frog   201 GMPAKKSVITYGCCSEPYPDVTYTLILKRRASFYIFNLLLPCVMISFLAPLGFYLPADSGEKVSL 265

  Fly   555 GVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSE 619
            |||:||:||||..:|||:|| .|:.|||:|.|:...|.|:.:|...||.|:|.||...:...:.:
Frog   266 GVTVLLALTVFQLLVAESMP-PSENVPLIGKYYIATMTMITASTALTIFIMNIHHCGPEAKPVPQ 329

  Fly   620 WIRIVFLCWLPWILRMSRPG----RPLILEFPTTPCSDTSSERKHQILS-DVELKERSSKSLLAN 679
            |.:...|.::..|..:...|    ||     .|.|  :.:|||..::.. |.:.|..       :
Frog   330 WAKKFILQYMSRIFFVYEVGESCRRP-----RTEP--EPNSERTSKVPGIDGQAKRE-------D 380

  Fly   680 VLDIDDDFRHNCRPMTPGG--TLPHNPAFYRTVYGQ---GDDGSIGP-IGSTRMPDAVTHHTCIK 738
            :.|:..|......|.....  .|.|:...:....|:   .:.|.:|. .|....|.  .|..|..
Frog   381 IADVVKDCPEKLSPKDKEAKEELEHSKYAHSQESGKYYVSEQGGVGKGFGYEECPK--IHCLCHN 443

  Fly   739 SSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVL 799
            ..       :||.|.:|.:..|..........:||..|.|:||..:.:|.:...|.::.::
Frog   444 ER-------LLKNIEYIANCFRDQRATQKRTGEWKKVAKVMDRFFMWVFFIMVFLMSVLIM 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	180/498 (36%)
chrna10	XP_031753261.1	LIC	27..496	CDD:273305	180/493 (37%)
chrna10	XP_031753261.1	LGIC_ECD_nAChR_A10	50..230	CDD:349824	83/180 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920