Protein Alignment nAChRalpha5 and LOC100334841

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: XP_009294780.1
• Gene: LOC100334841 / 100334841
• -ID: -
• Length: 467
• Species: Danio rerio
• Alignment Length: 530
• Identity: 133/530 - (25%)
• Similarity: 223/530 - (42%)
• Gaps: 107/530 - (20%)

  Fly   293 WIFLLIY-LNLSAKVCLAGYHEKRLLHDLLDP-YNTLE--------RPVLNESDPLQLSFGLTLM 347
            |.|||.| :.|:...||.  :..|.......| |.:|:        ||.:|.:.|...:...||.
Zfish     5 WHFLLAYFILLTVSPCLV--NMLRCEEGQSGPSYESLQEVINRKSFRPSINLNTPTITNISFTLY 67

  Fly   348 QIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGT 412
            .|:.|:||.|:|.|.:||:|.|....|.|.......:..:.:|...:|.||:::|...|   |..
Zfish    68 AILGVNEKAQILTTFLWLRLYWFHEFLIWEPELCDDITKISLPVADLWTPDIIVYEFVD---DDV 129

  Fly   413 YQT--NVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSW--TYDGFQLD--LQLQD 471
            .|.  .|.|.:.|...|.......|.|.:.|..||||.|.|...|||:  |....::.  |..::
Zfish   130 SQACPYVYVNHTGHIRYDRMLRLVSACNLQIFSFPFDIQNCTFTFGSYMHTIKDVRVSPALSFKE 194

  Fly   472 ETGGDISSYVLNGEWELLGVPGKRNEIYYNCCPEPYID----ITFAIIIRRRTLYYFFNLIIPCV 532
            .|.........:|||||:.:.|..:.:.:.      ||    |||.::|:||.:.|..|||||..
Zfish   195 MTENSKRYLQASGEWELVVILGDVDILNFG------IDEWDIITFWVVIKRRPILYVVNLIIPSA 253

  Fly   533 LIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFN-CIMFMVAS 596
            .:..:.:|.|.|||.|.::.|..:|::|..||||.::.:.:|:|::..||:|.||: |:..||.|
Zfish   254 FLMIIDILSFYLPPHSVDRSSFKMTLILGYTVFLLIMNDLLPSTANGTPLIGIYFSVCLALMVLS 318

  Fly   597 SVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEF----PTTPCSDTSSE 657
            .:.:.::....||.:.....:..|::::.:.::..::..|.|..|| .:|    .|.|....|:|
Zfish   319 LLETVLITCVLHHNSMKYRPVPHWVQVLVIRFIARLICYSFPEDPL-AKFEEKQDTNPWVAQSTE 382

  Fly   658 RKHQILSDVELKERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPI 722
                        ..|.:.:..|.                .||:
Zfish   383 ------------STSGQQIATNA----------------SGTM---------------------- 397

  Fly   723 GSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVD----RLC 783
             :..:|:.            .::...|||:......|||:|.   :.|.|.....::|    |:.
Zfish   398 -TLDVPEL------------RQISQDLKEMSTYLSILRKEDH---LQNQWCHVGYILDFLLFRIY 446

  Fly   784 LIIFTMFTIL 793
            |:|.|.:.::
Zfish   447 LLIITGYALV 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	125/509 (25%)
LOC100334841	XP_009294780.1	LIC	8..465	CDD:455710	131/527 (25%)
		LGIC_ECD	29..240	CDD:475126	61/219 (28%)