DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NimC4 and Pear1

DIOPT Version :9

Sequence 1:	NP_609698.2	Gene:	NimC4 / 34824	FlyBaseID:	FBgn0260011	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_001027585.1	Gene:	Pear1 / 73182	MGIID:	1920432	Length:	1034	Species:	Mus musculus

Alignment Length:	437	Identity:	92/437 - (21%)
Similarity:	136/437 - (31%)	Gaps:	174/437 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LILVLG---SIAANAERDNYCERNETIRATVPVTKQRIIVKQPSK-----WKIWKKTEKITEIYD 63
            |:|.||   :...|:...|.|...|:...|...:..|.....|::     |:......:.|.:|.
Mouse     7 LLLALGLRLTGTLNSNDPNVCTFWESFTTTTKESHLRPFSLLPAESCHRPWEDPHTCAQPTVVYR 71

  Fly    64 SEEEQVTHRLVR---ECCPGYLQVESGLCEPICSRGCPAHASCAAPDRCECISG----------- 114
            :...||.....|   :||.||.: ..|.|.|:|::.| .|..|.||::|:|..|
Mouse    72 TVYRQVVKMDSRPRLQCCRGYYE-SRGACVPLCAQEC-VHGRCVAPNQCQCAPGWRGGDCSSECA 134

  Fly   115 ---------------------------------------------------------YVSARNHQ 122
                                                                     |.::.:.|
Mouse   135 PGMWGPQCDKFCHCGNNSSCDPKSGTCFCPSGLQPPNCLQPCPAGHYGPACQFDCQCYGASCDPQ 199

  Fly   123 DGSHYCE-----PICETPC--------------------PAGAQCVTPNTCACRDGYTQL---QP 159
            ||:.:|.     |.|..||                    |.|:|    .:|:|..|:..:   .|
Mouse   200 DGACFCPPGRAGPSCNVPCSQGTDGFFCPRTYPCQNGGVPQGSQ----GSCSCPPGWMGVICSLP 260

  Fly   160 TDDGVSG-GCAPVCRVGDGCANGKCID--VDRCACNSGYRWDKAEERC-IELSAESISEELETTE 220
            ..:|..| .|...||    |.||...|  ..:|.|..||..|:.:|.| :....:..:|..:...
Mouse   261 CPEGFHGPNCTQECR----CHNGGLCDRFTGQCHCAPGYIGDRCQEECPVGRFGQDCAETCDCAP 321

  Fly   221 DNTDSPSTSSTAV---FTATH-----CPD---------------DFVL----FRGECREKQFDSN 258
            .....|:..:...   ||...     |||               :..|    ..|||      |.
Mouse   322 GARCFPANGACLCEHGFTGDRCTERLCPDGRYGLSCQEPCTCDPEHSLSCHPMHGEC------SC 380

  Fly   259 DVG-----CLKS--------GCGPHQTCL-------DSGVCQCSDGY 285
            ..|     |.:|        ||..|..||       |||:|:|:.||
Mouse   381 QPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGLCLADSGLCRCAPGY 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NimC4	NP_609698.2	None
Pear1	NP_001027585.1	EMI	25..93	CDD:284877	15/67 (22%)
		EGF_CA	535..580	CDD:304395
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	823..883
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	925..1034
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900