DRSC/TRiP Functional Genomics Resources

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Protein Alignment NimC4 and Megf10

DIOPT Version :10

Sequence 1:NP_609698.2 Gene:NimC4 / 34824 FlyBaseID:FBgn0260011 Length:377 Species:Drosophila melanogaster
Sequence 2:NP_001001979.1 Gene:Megf10 / 70417 MGIID:2685177 Length:1147 Species:Mus musculus


Alignment Length:348 Identity:84/348 - (24%)
Similarity:117/348 - (33%) Gaps:84/348 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 NAERDNYCERNE----TIRATVPVTKQRIIVKQPSKWKIWKKTEKITEIYDS---EEEQVTHRLV 74
            |.|..|.|...|    |::.:.|....:|.....:....|.|..:....|.:   ..|:..:|..
Mouse    27 NLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNWFKCTRHRISYRTAYRHGEKTMYRRK 91

  Fly    75 RECCPGYLQVESGLCEPICSRGCPAHASCAAPDRCECISGY--VSARNHQDGSHY---------- 127
            .:||||:.: ...:|.|.|:..| .|..|.||:.|:|..|:  .:..:..||.|:          
Mouse    92 SQCCPGFYE-SRDMCVPHCADKC-VHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCSSRCQC 154

  Fly   128 -----CEPI--------------CETPCPAG---------AQCVTPNT-------CACRDGYTQL 157
                 |.||              ||..|..|         .||....|       |.|..|||..
Mouse   155 KNRALCNPITGACHCAAGYRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHITGECRCSPGYTGA 219

  Fly   158 QPTDDGVSGGCAPVCRVGDGCAN-GKCIDV-DRCACNSGYRWDKAEERCIE-LSAESISEELETT 219
            ...|....|...|.|.....|.| |.|..| ..|:|.||:......:.|.| ...::.|:|.:..
Mouse   220 FCEDLCPPGKHGPHCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCH 284

  Fly   220 EDNTDSPSTSSTAVFTATHCPDDFVLFRGE-CREKQFDSNDVGCLKSGCGPHQTCLD-------S 276
            ...|...:|..      .||...:.   || |:    |...||.....|.....|::       |
Mouse   285 NGGTCDAATGQ------CHCSPGYT---GERCQ----DECPVGSYGVRCAEACRCVNGGKCYHVS 336

  Fly   277 GVCQCSDGYVPEESGEATGVLSC 299
            |.|.|..|:    |||......|
Mouse   337 GTCLCEAGF----SGELCEARLC 355

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NimC4NP_609698.2 None
Megf10NP_001001979.1 Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern. /evidence=ECO:0000250|UniProtKB:Q96KG7 1..857 84/348 (24%)
EMI 31..100 CDD:462204 15/68 (22%)
EGF_Lam 281..318 CDD:214543 10/49 (20%)
EGF_CA 542..587 CDD:473889
Necessary for formation of large intracellular vacuoles. /evidence=ECO:0000250|UniProtKB:Q96KG7 945..1147
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1093..1147
Blue background indicates that the domain is not in the aligned region.

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