DRSC/TRiP Functional Genomics Resources

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Protein Alignment NimC4 and Megf10

DIOPT Version :9

Sequence 1:NP_609698.2 Gene:NimC4 / 34824 FlyBaseID:FBgn0260011 Length:377 Species:Drosophila melanogaster
Sequence 2:NP_001001979.1 Gene:Megf10 / 70417 MGIID:2685177 Length:1147 Species:Mus musculus


Alignment Length:348 Identity:84/348 - (24%)
Similarity:117/348 - (33%) Gaps:84/348 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 NAERDNYCERNE----TIRATVPVTKQRIIVKQPSKWKIWKKTEKITEIYDS---EEEQVTHRLV 74
            |.|..|.|...|    |::.:.|....:|.....:....|.|..:....|.:   ..|:..:|..
Mouse    27 NLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNWFKCTRHRISYRTAYRHGEKTMYRRK 91

  Fly    75 RECCPGYLQVESGLCEPICSRGCPAHASCAAPDRCECISGY--VSARNHQDGSHY---------- 127
            .:||||:.: ...:|.|.|:..| .|..|.||:.|:|..|:  .:..:..||.|:          
Mouse    92 SQCCPGFYE-SRDMCVPHCADKC-VHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCSSRCQC 154

  Fly   128 -----CEPI--------------CETPCPAG---------AQCVTPNT-------CACRDGYTQL 157
                 |.||              ||..|..|         .||....|       |.|..|||..
Mouse   155 KNRALCNPITGACHCAAGYRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHITGECRCSPGYTGA 219

  Fly   158 QPTDDGVSGGCAPVCRVGDGCAN-GKCIDV-DRCACNSGYRWDKAEERCIE-LSAESISEELETT 219
            ...|....|...|.|.....|.| |.|..| ..|:|.||:......:.|.| ...::.|:|.:..
Mouse   220 FCEDLCPPGKHGPHCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCH 284

  Fly   220 EDNTDSPSTSSTAVFTATHCPDDFVLFRGE-CREKQFDSNDVGCLKSGCGPHQTCLD-------S 276
            ...|...:|..      .||...:.   || |:    |...||.....|.....|::       |
Mouse   285 NGGTCDAATGQ------CHCSPGYT---GERCQ----DECPVGSYGVRCAEACRCVNGGKCYHVS 336

  Fly   277 GVCQCSDGYVPEESGEATGVLSC 299
            |.|.|..|:    |||......|
Mouse   337 GTCLCEAGF----SGELCEARLC 355

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NimC4NP_609698.2 None
Megf10NP_001001979.1 Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern. /evidence=ECO:0000250|UniProtKB:Q96KG7 1..857 84/348 (24%)
EMI 32..99 CDD:284877 15/66 (23%)
EGF_CA 281..326 CDD:304395 11/57 (19%)
EGF_CA 542..587 CDD:304395
Necessary for formation of large intracellular vacuoles. /evidence=ECO:0000250|UniProtKB:Q96KG7 945..1147
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1093..1147
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1218
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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